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Int. J. Mol. Sci. 2015, 16(12), 29971-29979; doi:10.3390/ijms161226217

Stem Cell Replacement Improves Expression of SMP30 in db/db Mice

Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka 5731010, Japan
Department of Cardiac Surgery, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing 100029, China
Department of Microbiology, Kansai Medical University, Hirakata City, Osaka 5731010, Japan
Division of Clinical Pathology, Toyooka Hospital, Hyogo 6688501, Japan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Wilhelm Bloch
Received: 28 October 2015 / Revised: 4 December 2015 / Accepted: 9 December 2015 / Published: 16 December 2015
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
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We have previously reported that replacing bone marrow stem cells may improve hyperglycemia and oxidative stress in db/db mice, a type 2 diabetic mouse model. Senescence marker protein 30 (SMP30) is an antioxidant protein that decreases with aging. However, it has not been clear whether SMP30 decreases in the livers of obese mice, and whether stem cell replacement would improve SMP30 expression in the liver. Bone marrow stem cells of db/db mice were replaced with the bone marrow stem cells of C57BL/6 mice. Plasma cytokine and insulin levels were measured, and glycogen content, expression of SMP30, and fibrosis in the liver were assessed. Our results showed that stem cell replacement increased the expression of SMP30 in the liver, resulting from decreased plasma inflammation cytokines and hyperinsulinemia in db/db mice. This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db mice. View Full-Text
Keywords: SMP30; stem cell replacement; cytokines; fibrosis SMP30; stem cell replacement; cytokines; fibrosis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, M.; Guo, K.; Taketani, S.; Adachi, Y.; Ikehara, S. Stem Cell Replacement Improves Expression of SMP30 in db/db Mice. Int. J. Mol. Sci. 2015, 16, 29971-29979.

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