Proteins and Their Interacting Partners: An Introduction to Protein–Ligand Binding Site Prediction Methods
AbstractElucidating the biological and biochemical roles of proteins, and subsequently determining their interacting partners, can be difficult and time consuming using in vitro and/or in vivo methods, and consequently the majority of newly sequenced proteins will have unknown structures and functions. However, in silico methods for predicting protein–ligand binding sites and protein biochemical functions offer an alternative practical solution. The characterisation of protein–ligand binding sites is essential for investigating new functional roles, which can impact the major biological research spheres of health, food, and energy security. In this review we discuss the role in silico methods play in 3D modelling of protein–ligand binding sites, along with their role in predicting biochemical functionality. In addition, we describe in detail some of the key alternative in silico prediction approaches that are available, as well as discussing the Critical Assessment of Techniques for Protein Structure Prediction (CASP) and the Continuous Automated Model EvaluatiOn (CAMEO) projects, and their impact on developments in the field. Furthermore, we discuss the importance of protein function prediction methods for tackling 21st century problems. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Roche, D.B.; Brackenridge, D.A.; McGuffin, L.J. Proteins and Their Interacting Partners: An Introduction to Protein–Ligand Binding Site Prediction Methods. Int. J. Mol. Sci. 2015, 16, 29829-29842.
Roche DB, Brackenridge DA, McGuffin LJ. Proteins and Their Interacting Partners: An Introduction to Protein–Ligand Binding Site Prediction Methods. International Journal of Molecular Sciences. 2015; 16(12):29829-29842.Chicago/Turabian Style
Roche, Daniel B.; Brackenridge, Danielle A.; McGuffin, Liam J. 2015. "Proteins and Their Interacting Partners: An Introduction to Protein–Ligand Binding Site Prediction Methods." Int. J. Mol. Sci. 16, no. 12: 29829-29842.