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Open AccessCommunication
Int. J. Mol. Sci. 2015, 16(12), 29673-29681; doi:10.3390/ijms161226130

One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon

1
Institute for Energy Security and Environmental Safety, Centre for Energy Research, Hungarian Academy of Sciences, Budapest H-1121, Hungary
2
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest H-1111, Hungary
3
Óbuda University, Sándor Rejtő Faculty of Light Industry and Environmental Engineering, Budapest H-1034, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Malcolm D´Souza
Received: 29 September 2015 / Revised: 9 November 2015 / Accepted: 11 November 2015 / Published: 11 December 2015
(This article belongs to the Special Issue Solution Chemical Kinetics)
View Full-Text   |   Download PDF [1167 KB, uploaded 11 December 2015]   |  

Abstract

Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron reduction mechanism of selected penicillin derivatives using pulse radiolysis techniques. Penicillins can accommodate the electron on each of their carbonyl carbon. Ketyl radicals are thus produced, which are reducing agents with possibility to interact with suitable biomolecules. A detailed mechanism of the reduction is reported. View Full-Text
Keywords: antibiotic; penicillin; oxidative stress; reactive oxygen species; reduction; hydrated electron; ketyl radical; pulse radiolysis antibiotic; penicillin; oxidative stress; reactive oxygen species; reduction; hydrated electron; ketyl radical; pulse radiolysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Szabó, L.; Tóth, T.; Takács, E.; Wojnárovits, L. One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon. Int. J. Mol. Sci. 2015, 16, 29673-29681.

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