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Int. J. Mol. Sci. 2015, 16(12), 29643-29653; doi:10.3390/ijms161226192

Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer

1
Laboratory for Molecular Cellular Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, A-1090 Vienna, Austria
2
Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
3
Comprehensive Cancer Center (CCC), Medical University of Vienna, A-1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 23 October 2015 / Revised: 27 November 2015 / Accepted: 3 December 2015 / Published: 10 December 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
View Full-Text   |   Download PDF [390 KB, uploaded 10 December 2015]   |  

Abstract

Like other RECQ helicases, WRN/RECQL2 plays a crucial role in DNA replication and the maintenance of genome stability. Inactivating mutations in RECQL2 lead to Werner syndrome, a rare autosomal disease associated with premature aging and an increased susceptibility to multiple cancer types. We analyzed the association of two coding single-nucleotide polymorphisms in WRN, Cys1367Arg (rs1346044), and Arg834Cys (rs3087425), with the risk, age at onset, and clinical subclasses of breast cancer in a hospital-based case-control study of an Austrian population of 272 breast cancer patients and 254 controls. Here we report that the rare homozygous CC genotype of rs1346044 was associated with an approximately two-fold elevated breast cancer risk. Moreover, patients with the CC genotype exhibited a significantly increased risk of developing breast cancer under the age of 55 in both recessive and log-additive genetic models. CC patients developed breast cancer at a mean age of 55.2 ± 13.3 years and TT patients at 60.2 ± 14.7 years. Consistently, the risk of breast cancer was increased in pre-menopausal patients in the recessive model. These findings suggest that the CC genotype of WRN rs1346044 may contribute to an increased risk and a premature onset of breast cancer. View Full-Text
Keywords: breast cancer; Werner syndrome; WRN; RECQL2; rs1346044; rs3087425; single nucleotide polymorphism (SNP) breast cancer; Werner syndrome; WRN; RECQL2; rs1346044; rs3087425; single nucleotide polymorphism (SNP)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zins, K.; Frech, B.; Taubenschuss, E.; Schneeberger, C.; Abraham, D.; Schreiber, M. Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer. Int. J. Mol. Sci. 2015, 16, 29643-29653.

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