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Int. J. Mol. Sci. 2015, 16(12), 29357-29369; doi:10.3390/ijms161226172

IL-18 and Cutaneous Inflammatory Diseases

1
Department of Dermatology, Seoul St Mary’s Hospital, College of Medicine, the Catholic University of Korea, Seoul 137-701, Korea
2
Department of Life Science, Sookmyung Women’s University, Seoul 140-742, Korea
3
Department of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 6 November 2015 / Revised: 25 November 2015 / Accepted: 3 December 2015 / Published: 9 December 2015
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [2182 KB, uploaded 9 December 2015]   |  

Abstract

Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities. View Full-Text
Keywords: IL-18; psoriasis; atopic dermatitis; urticaria; contact dermatitis; alopecia areata; drug eruption; lupus erythematosus; fibrosis; graft-versus-host disease; skin tumor; skin disease IL-18; psoriasis; atopic dermatitis; urticaria; contact dermatitis; alopecia areata; drug eruption; lupus erythematosus; fibrosis; graft-versus-host disease; skin tumor; skin disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lee, J.H.; Cho, D.H.; Park, H.J. IL-18 and Cutaneous Inflammatory Diseases. Int. J. Mol. Sci. 2015, 16, 29357-29369.

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