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Int. J. Mol. Sci. 2015, 16(12), 28063-28076; doi:10.3390/ijms161226080

MicroRNAs: Clinical Relevance in Colorectal Cancer

1
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
2
Division of Oncology, Medical University of Graz, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Constantinos Stathopoulos
Received: 3 September 2015 / Revised: 27 October 2015 / Accepted: 13 November 2015 / Published: 25 November 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [377 KB, uploaded 25 November 2015]   |  

Abstract

Colorectal cancer is one of the most common cancer diagnoses and causes of mortality worldwide. MicroRNAs are a class of small, non-coding regulatory RNAs that have shown strong associations with colorectal cancer. Through the repression of target messenger RNAs, microRNAs modulate many cellular pathways, such as those involved in cell proliferation, apoptosis, and differentiation. The utilization of microRNAs has shown significant promise in the diagnosis and prognosis of colorectal cancer, owing to their unique expression profile associations with cancer types and malignancies. Moreover, microRNA therapeutics with mimics or antagonists show great promise in preclinical studies, which encourages further development of their clinical use for colorectal cancer patients. The unique ability of microRNAs to affect multiple downstream pathways represents a novel approach for cancer therapy. Although still early in its development, we believe that microRNAs can be used in the near future as biomarkers and therapeutic targets for colorectal cancer. View Full-Text
Keywords: colorectal cancer; miRNA; pathophysiology; diagnosis; prognosis; treatment colorectal cancer; miRNA; pathophysiology; diagnosis; prognosis; treatment
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Thomas, J.; Ohtsuka, M.; Pichler, M.; Ling, H. MicroRNAs: Clinical Relevance in Colorectal Cancer. Int. J. Mol. Sci. 2015, 16, 28063-28076.

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