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Int. J. Mol. Sci. 2015, 16(11), 27978-27987; doi:10.3390/ijms161126071

Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi

1
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
2
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China
3
School of Public Health, Jilin University, Changchun 130021, China
4
Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Ge Zhang
Received: 17 September 2015 / Revised: 26 October 2015 / Accepted: 13 November 2015 / Published: 24 November 2015
View Full-Text   |   Download PDF [2331 KB, uploaded 24 November 2015]   |  

Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2). View Full-Text
Keywords: Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, W.-F.; Wang, J.; Zhang, J.-J.; Song, X.; Ku, C.-F.; Zou, J.; Li, J.-X.; Rong, L.-J.; Pan, L.-T.; Zhang, H.-J. Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi. Int. J. Mol. Sci. 2015, 16, 27978-27987.

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