The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33
AbstractIL-33 is a new member of the IL-1 family cytokines, which is expressed by different types of immune cells and non-immune cells. IL-33 is constitutively expressed in the nucleus, where it can act as a transcriptional regulator. So far, no direct target for nuclear IL-33 has been identified, and the regulation of IL-33 nuclear function remains largely unclear. Here, we report that the transcription of type 2 inflammatory cytokine IL-13 is positively regulated by nuclear IL-33. IL-33 can directly bind to the conserved non-coding sequence (CNS) before the translation initiation site in the IL13 gene locus. Moreover, IL-33 nuclear function and stability are regulated by the enzyme ubiquitin-specific protease 17 (USP17) through deubiquitination of IL-33 both at the K48 and at the K63 sites. Our data suggest that IL13 gene transcription can be directly activated by nuclear IL-33, which is negatively regulated by the deubiquitinase USP17. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Ni, Y.; Tao, L.; Chen, C.; Song, H.; Li, Z.; Gao, Y.; Nie, J.; Piccioni, M.; Shi, G.; Li, B. The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33. Int. J. Mol. Sci. 2015, 16, 27956-27966.
Ni Y, Tao L, Chen C, Song H, Li Z, Gao Y, Nie J, Piccioni M, Shi G, Li B. The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33. International Journal of Molecular Sciences. 2015; 16(11):27956-27966.Chicago/Turabian Style
Ni, Yingmeng; Tao, Lianqin; Chen, Chen; Song, Huihui; Li, Zhiyuan; Gao, Yayi; Nie, Jia; Piccioni, Miranda; Shi, Guochao; Li, Bin. 2015. "The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33." Int. J. Mol. Sci. 16, no. 11: 27956-27966.