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Int. J. Mol. Sci. 2015, 16(11), 27956-27966; doi:10.3390/ijms161126063

The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33

1
Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2
Key Laboratory of Molecular Virology and Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Lee A. Bulla
Received: 31 August 2015 / Revised: 30 October 2015 / Accepted: 13 November 2015 / Published: 24 November 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

IL-33 is a new member of the IL-1 family cytokines, which is expressed by different types of immune cells and non-immune cells. IL-33 is constitutively expressed in the nucleus, where it can act as a transcriptional regulator. So far, no direct target for nuclear IL-33 has been identified, and the regulation of IL-33 nuclear function remains largely unclear. Here, we report that the transcription of type 2 inflammatory cytokine IL-13 is positively regulated by nuclear IL-33. IL-33 can directly bind to the conserved non-coding sequence (CNS) before the translation initiation site in the IL13 gene locus. Moreover, IL-33 nuclear function and stability are regulated by the enzyme ubiquitin-specific protease 17 (USP17) through deubiquitination of IL-33 both at the K48 and at the K63 sites. Our data suggest that IL13 gene transcription can be directly activated by nuclear IL-33, which is negatively regulated by the deubiquitinase USP17. View Full-Text
Keywords: IL-33; ubiquitin-specific protease 17 (USP17); IL-13; DNA binding; deubiquitinase IL-33; ubiquitin-specific protease 17 (USP17); IL-13; DNA binding; deubiquitinase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ni, Y.; Tao, L.; Chen, C.; Song, H.; Li, Z.; Gao, Y.; Nie, J.; Piccioni, M.; Shi, G.; Li, B. The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33. Int. J. Mol. Sci. 2015, 16, 27956-27966.

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