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Int. J. Mol. Sci. 2015, 16(11), 27371-27377; doi:10.3390/ijms161126033

The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma

1
Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan
2
Graduate Institute of Biomedical Science, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan
3
Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, 5 Fu-Hsing Street, Kweishan, Taoyuan 33375, Taiwan
4
Department of Anatomy, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan
5
Department of Chemical Engineering, Ming Chi University of Technology, 84 Gung-Juan Road, Taishan, New Taipei 24301, Taiwan
6
Department of Microbiology, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan
7
Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan
8
Department of Ophthalmology, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Kweishan, Taoyuan 33375, Taiwan
9
Department of Environment and Biotechnology, Refining and Manufacturing Research Institute, CPC Corporation, Chiayi, 217 Min-Sheng S. Rd, Chiayi 60051, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Hitoshi Sashiwa and Shinsuke Ifuku
Received: 13 August 2015 / Revised: 24 September 2015 / Accepted: 5 November 2015 / Published: 16 November 2015
(This article belongs to the Special Issue Chitins 2015)
View Full-Text   |   Download PDF [1361 KB, uploaded 16 November 2015]   |  

Abstract

Asthma is the result of chronic inflammation of the airways which subsequently results in airway hyper-responsiveness and airflow obstruction. It has been shown that an elicited expression of acidic mammalian chitinase (AMCase) may be involved in the pathogenesis of asthma. Our recent study has demonstrated that the specific suppression of elevated AMCase leads to reduced eosinophilia and Th2-mediated immune responses in an ovalbumin (OVA)-sensitized mouse model of allergic asthma. In the current study, we show that the elicited expression of AMCase in the lung tissues of both ovalbumin- and Der P2-induced allergic asthma mouse models. The effects of allergic mediated molecules on AMCase expression were evaluated by utilizing promoter assay in the lung cells. In fact, the exposure of chitin, a polymerized sugar and the fundamental component of the major allergen mite and several of the inflammatory mediators, showed significant enhancement on AMCase expression. Such obtained results contribute to the basis of developing a promising therapeutic strategy for asthma by silencing AMCase expression. View Full-Text
Keywords: allergy; asthma; chitinase; promoter allergy; asthma; chitinase; promoter
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MDPI and ACS Style

Shen, C.-R.; Juang, H.-H.; Chen, H.-S.; Yang, C.-J.; Wu, C.-J.; Lee, M.-H.; Hwang, Y.-S.; Kuo, M.-L.; Chen, Y.-S.; Chen, J.-K.; Liu, C.-L. The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma. Int. J. Mol. Sci. 2015, 16, 27371-27377.

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