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Int. J. Mol. Sci. 2015, 16(11), 27327-27338; doi:10.3390/ijms161126027

The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria

1
Private Practice, Zahnarztpraxis an der Murg, Metzgerstrasse 1, Frauenfeld CH 8500, Switzerland
2
Center of Dental Medicine, Clinic of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, Zürich CH 8032, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Michael R. Hamblin and Ying-ying Huang
Received: 29 July 2015 / Revised: 28 September 2015 / Accepted: 3 November 2015 / Published: 13 November 2015
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
View Full-Text   |   Download PDF [368 KB, uploaded 13 November 2015]   |  

Abstract

Periodontitis, an inflammatory disease, is caused by biofilms with a mixed microbial etiology and involves the progressive destruction of the tooth-supporting tissues. A rising number of studies investigate the clinical potential of photodynamic therapy (PDT) as an adjunct during active therapy. The aim of the present review was to evaluate the available literature for the in vitro antimicrobial efficacy of photodynamic therapy focusing on the periodontopathogenic bacteria Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum. The focused question was: “Is it possible to decrease (at least 3 log steps or 99.9%) or even eliminate bacterial growth by photodynamic therapy in vitro when compared to untreated control groups or control groups treated by placebo?” In general, PDT resulted in a substantial reduction of surviving bacteria. However, not all studies showed the desired reduction or elimination. The ranges of log10-reduction were 0.38 (58%) to a complete eradication (100%) for P. gingivalis, 0.21 (39%) to 100% for A. actinomycetemcomitans and 0.3 (50%) to 100% for F. nucleatum. In conclusion, further and particularly more comparable studies are needed to evaluate if PDT can be clinically successful as an adjuvant in periodontal therapy. View Full-Text
Keywords: PDT; photodynamic therapy; in vitro; periodontitis; antimicrobial activity PDT; photodynamic therapy; in vitro; periodontitis; antimicrobial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Haag, P.A.; Steiger-Ronay, V.; Schmidlin, P.R. The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria. Int. J. Mol. Sci. 2015, 16, 27327-27338.

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