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Int. J. Mol. Sci. 2015, 16(11), 27072-27086; doi:10.3390/ijms161125999

A Comparative Study on Two Cationic Porphycenes: Photophysical and Antimicrobial Photoinactivation Evaluation

1
Institut Químic de Sarrià, Universitat Ramon Llull, via Augusta 390, E-08017 Barcelona, Spain
2
Department of Biology, University of Padova, via U. Bassi 58/B, E-35121 Padova, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Ying-ying Huang
Received: 29 July 2015 / Revised: 19 October 2015 / Accepted: 2 November 2015 / Published: 12 November 2015
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
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Abstract

Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes where photoinactivation efficiency against model pathogenic microorganisms is correlated to the photophysical behavior of the porphycene derivatives. Moreover, the extent of photosensitizer cell binding to bacteria has been assessed by flow cytometry in experiments with, or without, removing the unbound porphycene from the incubation medium. Results show that the peripheral substituent change do not significantly affect the overall behavior for both tricationic compounds neither in terms of photokilling efficiency, nor in terms of binding. View Full-Text
Keywords: photodynamic therapy; antimicrobial photoinactivation; MRSA; P. aeruginosa; photosensitizer; porphycene; flow cytometry; singlet oxygen photodynamic therapy; antimicrobial photoinactivation; MRSA; P. aeruginosa; photosensitizer; porphycene; flow cytometry; singlet oxygen
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ruiz-González, R.; Agut, M.; Reddi, E.; Nonell, S. A Comparative Study on Two Cationic Porphycenes: Photophysical and Antimicrobial Photoinactivation Evaluation. Int. J. Mol. Sci. 2015, 16, 27072-27086.

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