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Int. J. Mol. Sci. 2015, 16(11), 26936-26952; doi:10.3390/ijms161125995

Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy

1
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China
2
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
3
Changshu Research Institute, Hong Kong Baptist University, Changshu Economic and Technological Development (CETD) Zone, Changshu 215500, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Ritva Tikkanen
Received: 28 September 2015 / Revised: 29 October 2015 / Accepted: 30 October 2015 / Published: 11 November 2015
View Full-Text   |   Download PDF [788 KB, uploaded 11 November 2015]   |  

Abstract

Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death in the world. Currently available chemotherapy of CRC usually delivers the drug to both normal as well as cancerous tissues, thus leading to numerous undesirable effects. Much emphasis is being laid on the development of effective drug delivery systems for achieving selective delivery of the active moiety at the anticipated site of action with minimized unwanted side effects. Researchers have employed various techniques (dependent on pH, time, pressure and/or bacteria) for targeting drugs directly to the colonic region. On the other hand, systemic drug delivery strategies to specific molecular targets (such as FGFR, EGFR, CD44, EpCAM, CA IX, PPARγ and COX-2) overexpressed by cancerous cells have also been shown to be effective. This review aims to put forth an overview of drug delivery technologies that have been, and may be developed, for the treatment of CRC. View Full-Text
Keywords: colorectal cancer; chemotherapy; drug delivery system; colon-specific drug delivery system; systemic drug delivery system colorectal cancer; chemotherapy; drug delivery system; colon-specific drug delivery system; systemic drug delivery system
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lin, C.; Ng, H.L.H.; Pan, W.; Chen, H.; Zhang, G.; Bian, Z.; Lu, A.; Yang, Z. Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. Int. J. Mol. Sci. 2015, 16, 26936-26952.

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