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Int. J. Mol. Sci. 2015, 16(11), 26706-26720; doi:10.3390/ijms161125975

Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis

1
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
2
Division of Internal Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
3
Department of Molecular Cardiology, Texas Heart Institute, Houston, TX 77030, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Salvador Ventura
Received: 21 September 2015 / Revised: 22 October 2015 / Accepted: 26 October 2015 / Published: 6 November 2015
(This article belongs to the Collection Protein Folding)
View Full-Text   |   Download PDF [1256 KB, uploaded 6 November 2015]   |  

Abstract

The folding of newly synthesized proteins and the maintenance of pre-existing proteins are essential in sustaining a living cell. A network of molecular chaperones tightly guides the folding, intracellular localization, and proteolytic turnover of proteins. Many of the key regulators of cell growth and differentiation have been identified as clients of molecular chaperones, which implies that chaperones are potential mediators of oncogenesis. In this review, we briefly provide an overview of the role of chaperones, including HSP70 and HSP90, in cancer. We further summarize and highlight the emerging the role of chaperonin TRiC (T-complex protein-1 ring complex, also known as CCT) in the development and progression of cancer mediated through its critical interactions with oncogenic clients that modulate growth deregulation, apoptosis, and genome instability in cancer cells. Elucidation of how TRiC modulates the folding and function of oncogenic clients will provide strategies for developing novel cancer therapies. View Full-Text
Keywords: protein-folding; proteostasis; oncogenesis; chaperone; chaperonin; HSP70/90; TRiC/CCT; oncoprotein protein-folding; proteostasis; oncogenesis; chaperone; chaperonin; HSP70/90; TRiC/CCT; oncoprotein
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Roh, S.-H.; Kasembeli, M.; Bakthavatsalam, D.; Chiu, W.; Tweardy, D.J. Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int. J. Mol. Sci. 2015, 16, 26706-26720.

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