Next Article in Journal
Notch Cooperates with Survivin to Maintain Stemness and to Stimulate Proliferation in Human Keratinocytes during Ageing
Next Article in Special Issue
Short- and Long-Term Effects of Prenatal Exposure to Iron Oxide Nanoparticles: Influence of Surface Charge and Dose on Developmental and Reproductive Toxicity
Previous Article in Journal
Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome
Previous Article in Special Issue
In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(11), 26280-26290; doi:10.3390/ijms161125960

Genotoxicity of Superparamagnetic Iron Oxide Nanoparticles in Granulosa Cells

1
Department of Otorhinolaryngology, Head and Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, University Hospital Erlangen, Glückstraße 10a, Erlangen 91054, Germany
2
Department of Obstetrics and Gynecology, Ludwig Maximilians University of Munich, Maistraße 11, Munich 80337, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Yuping Bao
Received: 31 August 2015 / Revised: 13 October 2015 / Accepted: 15 October 2015 / Published: 3 November 2015
(This article belongs to the Special Issue Developmental and Reproductive Toxicity of Iron Oxide Nanoparticles)
View Full-Text   |   Download PDF [2147 KB, uploaded 3 November 2015]   |  

Abstract

Nanoparticles that are aimed at targeting cancer cells, but sparing healthy tissue provide an attractive platform of implementation for hyperthermia or as carriers of chemotherapeutics. According to the literature, diverse effects of nanoparticles relating to mammalian reproductive tissue are described. To address the impact of nanoparticles on cyto- and genotoxicity concerning the reproductive system, we examined the effect of superparamagnetic iron oxide nanoparticles (SPIONs) on granulosa cells, which are very important for ovarian function and female fertility. Human granulosa cells (HLG-5) were treated with SPIONs, either coated with lauric acid (SEONLA) only, or additionally with a protein corona of bovine serum albumin (BSA; SEONLA-BSA), or with dextran (SEONDEX). Both micronuclei testing and the detection of γH2A.X revealed no genotoxic effects of SEONLA-BSA, SEONDEX or SEONLA. Thus, it was demonstrated that different coatings of SPIONs improve biocompatibility, especially in terms of genotoxicity towards cells of the reproductive system. View Full-Text
Keywords: superparamagnetic iron oxide nanoparticles; protein corona; cancer therapy and diagnosis; reproductive health; granulosa cells superparamagnetic iron oxide nanoparticles; protein corona; cancer therapy and diagnosis; reproductive health; granulosa cells
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pöttler, M.; Staicu, A.; Zaloga, J.; Unterweger, H.; Weigel, B.; Schreiber, E.; Hofmann, S.; Wiest, I.; Jeschke, U.; Alexiou, C.; Janko, C. Genotoxicity of Superparamagnetic Iron Oxide Nanoparticles in Granulosa Cells. Int. J. Mol. Sci. 2015, 16, 26280-26290.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top