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Open AccessCommunication
Int. J. Mol. Sci. 2015, 16(10), 24588-24599; doi:10.3390/ijms161024588

Poly-γ-glutamate-based Materials for Multiple Infection Prophylaxis Possessing Versatile Coating Performance

Graduate School of Integrated Arts and Sciences, Kochi University, Kochi 783-8502, Japan
Faculty of Agriculture, Kochi University, Nankoku, Kochi 783-8502, Japan
Research Center, Toyobo Co., Otsu, Shiga 520-0292, Japan
Author to whom correspondence should be addressed.
Academic Editor: Antonella Piozzi
Received: 1 September 2015 / Revised: 29 September 2015 / Accepted: 8 October 2015 / Published: 15 October 2015
(This article belongs to the Special Issue Antimicrobial Polymers 2016)
View Full-Text   |   Download PDF [1965 KB, uploaded 15 October 2015]   |  


Poly-γ-glutamate (PGA) possesses a nylon-like backbone and polyacrylate-like carboxyl groups, and shows an extraordinary solubility in water. In this study, the effective synthesis and structural analysis of some water-insoluble PGA ion-complexes (PGAICs) using cationic surfactants, hexadecylpyridinium (HDP), dodecylpyridinium, benzalkonium and benzetonium, were examined. We demonstrated their spontaneous coating performance to the surfaces of different materials (i.e., plastics, metals, and ceramics) as potent anti-staphylococcal and anti-Candida agents. The tests against Staphylococcus aureus revealed that, regardless of a variety of materials, PGAICs maintained surface antimicrobial activity, even after the water-soaking treatment, whereas those against Candida albicans indicated that, among PGAICs, PGA/HDP complex is most useful as an anti-fungal agent because of its coating stability. Moreover, the log reduction values against Influenza A and B viruses of PGA/HDP-coated surfaces were estimated to be 5.4 and 3.2, respectively, suggesting that it can be dramatically suppressed the infection of influenza. This is to our knowledge the first observation of PGA-based antiviral coatings. View Full-Text
Keywords: poly-γ-glutamate; antibacterial; antiviral; coating activity; anionic polyamide; cationic surfactants poly-γ-glutamate; antibacterial; antiviral; coating activity; anionic polyamide; cationic surfactants

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ashiuchi, M.; Hakumai, Y.; Shibatani, S.; Hakuba, H.; Oka, N.; Kobayashi, H.; Yoneda, K. Poly-γ-glutamate-based Materials for Multiple Infection Prophylaxis Possessing Versatile Coating Performance. Int. J. Mol. Sci. 2015, 16, 24588-24599.

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