Next Article in Journal
Identification and Functional Analysis of MicroRNAs in Mice following Focal Cerebral Ischemia Injury
Next Article in Special Issue
Genetics Underlying Atypical Parkinsonism and Related Neurodegenerative Disorders
Previous Article in Journal
Metabolic and Physiological Responses of Shiraz and Cabernet Sauvignon (Vitis vinifera L.) to Near Optimal Temperatures of 25 and 35 °C
Previous Article in Special Issue
Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(10), 24295-24301; doi:10.3390/ijms161024295

Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication

Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
*
Author to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Received: 15 August 2015 / Revised: 11 September 2015 / Accepted: 18 September 2015 / Published: 14 October 2015
(This article belongs to the Special Issue Mechanisms of Neurodegeneration)
View Full-Text   |   Download PDF [694 KB, uploaded 14 October 2015]   |  

Abstract

One of the most conspicuous features of neurodegenerative diseases (NDs) is the occurrence of dramatic conformation change of individual proteins. We performed a mutational spectrum analysis of disease-causing missense mutations in seven types of NDs at nucleotide and amino acid levels, and compared the results with those of non-NDs. The main findings included: (i) The higher mutation ratio of G:C→T:A transversion to G:C→A:T transition was observed in NDs than in non-NDs, interpreting the excessive guanine-specific oxidative DNA damage in NDs; (ii) glycine and proline had highest mutability in NDs than in non-NDs, which favor the protein conformation change in NDs; (iii) surprisingly low mutation frequency of arginine was observed in NDs. These findings help to understand how mutations may cause NDs. View Full-Text
Keywords: neurodegenerative diseases; conformation change; mutation; distribution pattern; pathogenesis neurodegenerative diseases; conformation change; mutation; distribution pattern; pathogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shen, L.; Ji, H.-F. Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication. Int. J. Mol. Sci. 2015, 16, 24295-24301.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top