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Int. J. Mol. Sci. 2015, 16(1), 736-746; doi:10.3390/ijms16010736

Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
2
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan
3
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan
4
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
5
Department of Biology, National Changhua University of Education, Changhua 50007, Taiwan
6
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 18 November 2014 / Accepted: 17 December 2014 / Published: 30 December 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [743 KB, uploaded 30 December 2014]   |  

Abstract

A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 16 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils. View Full-Text
Keywords: Homoeostrichus formosana; chromenes; cytotoxicity; antibacterial; anti-inflammatory Homoeostrichus formosana; chromenes; cytotoxicity; antibacterial; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fang, H.-Y.; Chokkalingam, U.; Chiou, S.-F.; Hwang, T.-L.; Chen, S.-L.; Wang, W.-L.; Sheu, J.-H. Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana. Int. J. Mol. Sci. 2015, 16, 736-746.

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