Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana
AbstractA new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils. View Full-Text
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Fang, H.-Y.; Chokkalingam, U.; Chiou, S.-F.; Hwang, T.-L.; Chen, S.-L.; Wang, W.-L.; Sheu, J.-H. Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana. Int. J. Mol. Sci. 2015, 16, 736-746.
Fang H-Y, Chokkalingam U, Chiou S-F, Hwang T-L, Chen S-L, Wang W-L, Sheu J-H. Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana. International Journal of Molecular Sciences. 2015; 16(1):736-746.Chicago/Turabian Style
Fang, Hui-Yu; Chokkalingam, Uvarani; Chiou, Shu-Fen; Hwang, Tsong-Long; Chen, Shu-Li; Wang, Wei-Lung; Sheu, Jyh-Horng. 2015. "Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana." Int. J. Mol. Sci. 16, no. 1: 736-746.