Next Article in Journal
Asymmetric Synthesis and Evaluation of Danshensu-Cysteine Conjugates as Novel Potential Anti-Apoptotic Drug Candidates
Next Article in Special Issue
A Hyaluronan-Based Scaffold for the in Vitro Construction of Dental Pulp-Like Tissue
Previous Article in Journal
Polyester-Based (Bio)degradable Polymers as Environmentally Friendly Materials for Sustainable Development
Previous Article in Special Issue
Recent Developments in β-Cell Differentiation of Pluripotent Stem Cells Induced by Small and Large Molecules
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(1), 597-627; doi:10.3390/ijms16010597

Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts

1
Centre for Nanotechnology & Regenerative Medicine, Research Department of Nanotechnology, UCL Division of Surgery & Interventional Science, University College London (UCL), London NW3 2QG, UK
2
UCL Medical School, University College London (UCL), London WC1E 6DE, UK
3
Biomaterials & Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94304, USA
4
University Department of Surgery, Royal Free London NHS Foundation Trust Hospital, London NW3 2QG, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Kevin D. Belfield
Received: 28 September 2014 / Accepted: 19 December 2014 / Published: 29 December 2014
(This article belongs to the Special Issue Artificial Organs)
View Full-Text   |   Download PDF [2017 KB, uploaded 29 December 2014]   |  

Abstract

The patency of synthetic cardiovascular grafts in the long run is synonymous with their ability to inhibit the processes of intimal hyperplasia, thrombosis and calcification. In the human body, the endothelium of blood vessels exhibits characteristics that inhibit such processes. As such it is not surprising that research in tissue engineering is directed towards replicating the functionality of the natural endothelium in cardiovascular grafts. This can be done either by seeding the endothelium within the lumen of the grafts prior to implantation or by designing the graft such that in situ endothelialisation takes place after implantation. Due to certain difficulties identified with in vitro endothelialisation, in situ endothelialisation, which will be the focus of this article, has garnered interest in the last years. To promote in situ endothelialisation, the following aspects can be taken into account: (1) Endothelial progenital cell mobilization, adhesion and proliferation; (2) Regulating differentiation of progenitor cells to mature endothelium; (3) Preventing thrombogenesis and inflammation during endothelialisation. This article aims to review and compile recent developments to promote the in situ endothelialisation of cardiovascular grafts and subsequently improve their patency, which can also have widespread implications in the field of tissue engineering. View Full-Text
Keywords: endothelialization; endothelial progenitor cells; bioengineered stents; nanotechnology; cardiology endothelialization; endothelial progenitor cells; bioengineered stents; nanotechnology; cardiology
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Goh, E.T.; Wong, E.; Farhatnia, Y.; Tan, A.; Seifalian, A.M. Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts. Int. J. Mol. Sci. 2015, 16, 597-627.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top