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Int. J. Mol. Sci. 2014, 15(9), 16975-16997; doi:10.3390/ijms150916975

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

1
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
2
Key Laboratory of Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
3
Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
4
Institute of Immunology, Medical and Health Science Center, University of Debrecen, Debrecen H-4012, Hungary
5
Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest H-1025, Hungary
6
Radiation Oncology and Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA
7
Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
*
Author to whom correspondence should be addressed.
Received: 7 August 2014 / Revised: 9 September 2014 / Accepted: 16 September 2014 / Published: 23 September 2014
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2014)
View Full-Text   |   Download PDF [2443 KB, uploaded 23 September 2014]   |  

Abstract

Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine’s lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1–BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation. View Full-Text
Keywords: OGG1; DNA base excision repair; 8-oxoG base; small GTPases; inflammation OGG1; DNA base excision repair; 8-oxoG base; small GTPases; inflammation
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MDPI and ACS Style

Ba, X.; Aguilera-Aguirre, L.; Rashid, Q.T.A.N.; Bacsi, A.; Radak, Z.; Sur, S.; Hosoki, K.; Hegde, M.L.; Boldogh, I. The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation. Int. J. Mol. Sci. 2014, 15, 16975-16997.

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