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Int. J. Mol. Sci. 2014, 15(9), 16680-16697; doi:10.3390/ijms150916680

Diversity in TAF Proteomics: Consequences for Cellular Differentiation and Migration

1,2,†,* and 1,3,†,*
1
Protobios LLC, Mäealuse 4, Tallinn 12618, Estonia
2
Cellin Technology LLC, Mäealuse 4, Tallinn 12618, Estonia
3
The Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 12618, Estonia
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 25 August 2014 / Accepted: 27 August 2014 / Published: 19 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [830 KB, uploaded 19 September 2014]   |  

Abstract

Development is a highly controlled process of cell proliferation and differentiation driven by mechanisms of dynamic gene regulation. Specific DNA binding factors for establishing cell- and tissue-specific transcriptional programs have been characterised in different cell and animal models. However, much less is known about the role of “core transcription machinery” during cell differentiation, given that general transcription factors and their spatiotemporally patterned activity govern different aspects of cell function. In this review, we focus on the role of TATA-box associated factor 4 (TAF4) and its functional isoforms generated by alternative splicing in controlling lineage-specific differentiation of normal mesenchymal stem cells and cancer stem cells. In the light of our recent findings, induction, control and maintenance of cell differentiation status implies diversification of the transcription initiation apparatus orchestrated by alternative splicing. View Full-Text
Keywords: TAF4; cell-specific transcription; alternative splicing; cancer stem cells TAF4; cell-specific transcription; alternative splicing; cancer stem cells
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Kazantseva, J.; Palm, K. Diversity in TAF Proteomics: Consequences for Cellular Differentiation and Migration. Int. J. Mol. Sci. 2014, 15, 16680-16697.

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