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Int. J. Mol. Sci. 2014, 15(9), 15512-15529; doi:10.3390/ijms150915512

Resveratrol Induces the Expression of Interleukin-10 and Brain-Derived Neurotrophic Factor in BV2 Microglia under Hypoxia

1
Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea
2
BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
3
Department of Anatomy, Gachon University School of Medicine, Incheon 406-799, Korea
*
Author to whom correspondence should be addressed.
Received: 15 May 2014 / Revised: 8 August 2014 / Accepted: 26 August 2014 / Published: 2 September 2014
(This article belongs to the Special Issue Pharmaceuticals and Nutraceuticals by Molecular Farming)
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Abstract

Microglia are the resident macrophages of the central nervous system (CNS) and play an important role in neuronal recovery by scavenging damaged neurons. However, overactivation of microglia leads to neuronal death that is associated with CNS disorders. Therefore, regulation of microglial activation has been suggested to be an important target for treatment of CNS diseases. In the present study, we investigated the beneficial effect of resveratrol, a natural phenol with antioxidant effects, in the microglial cell line, BV2, in a model of hypoxia injury. Resveratrol suppressed the mRNA expression of the pro-inflammatory molecule, tumor necrosis factor-α, and promoted the mRNA expression of the anti-inflammatory molecule, interleukin-10, in BV2 microglia under hypoxic conditions. In addition, resveratrol inhibited the activation of the transcription factor, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), which is upstream in the control of inflammatory reactions in hypoxia-injured BV2 microglia. Moreover, resveratrol promoted the expression of brain-derived neurotrophic factor (BDNF) in BV2 microglia under hypoxic stress. Overall, resveratrol may promote the beneficial function of microglia in ischemic brain injury. View Full-Text
Keywords: resveratrol; microglia; hypoxia; nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB); interleukin-10 (IL-10); brain-derived neurotrophic factor (BDNF) resveratrol; microglia; hypoxia; nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB); interleukin-10 (IL-10); brain-derived neurotrophic factor (BDNF)
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Song, J.; Cheon, S.Y.; Jung, W.; Lee, W.T.; Lee, J.E. Resveratrol Induces the Expression of Interleukin-10 and Brain-Derived Neurotrophic Factor in BV2 Microglia under Hypoxia. Int. J. Mol. Sci. 2014, 15, 15512-15529.

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