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Int. J. Mol. Sci. 2014, 15(9), 15259-15271; doi:10.3390/ijms150915259

The Adenosine Deaminase Gene Polymorphism Is Associated with Chronic Heart Failure Risk in Chinese

1
Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China
2
Department of Human Anatomy, Histology and Embryology, Medical College, Xi'an Jiaotong University, Xi'an 710061, China
3
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
4
Physical Examination Department, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 17 July 2014 / Revised: 19 August 2014 / Accepted: 22 August 2014 / Published: 28 August 2014
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
View Full-Text   |   Download PDF [696 KB, uploaded 28 August 2014]

Abstract

Adenosine (Ado) is an important cardioprotective agent. Since endogenous Ado levels are affected by the enzyme Ado deaminase (ADA), polymorphisms within the ADA gene may exert some effect on chronic heart failure (CHF). This study applied a case-control investigation to 300 northern Chinese Han CHF patients and 400 ethnicity-matched healthy controls in which nine single-nucleotide polymorphisms (SNPs) of ADA were genotyped and association analyses were performed. Odds ratios (ORs) with 95% confidence intervals (CI) were used to assess the association. Overall, rs452159 polymorphism in ADA gene was significantly associated with susceptibility to CHF under the dominant model (p = 0.013, OR = 1.537, 95% CI = 1.10–2.16), after adjustment for age, sex, and traditional cardiovascular risk factors. No difference in genotype distribution and allele frequency for the rs452159 according to the functional New York Heart Association class was found. Furthermore, the values of left ventricular ejection fraction, left-ventricle end-diastolic diameter or left-ventricle end-systolic diameter did not differ significantly among the different rs452159 genotype CHF patients. Although further studies with larger cohorts and other ethnicities are required to validate the conclusions, the findings of this study potentially provide novel insight into the pathogenesis of CHF. View Full-Text
Keywords: ADA; adenosine; chronic heart failure; SNP; rs452159 ADA; adenosine; chronic heart failure; SNP; rs452159
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

He, H.-R.; Li, Y.-J.; He, G.-H.; Wang, Y.-J.; Zhai, Y.-J.; Xie, J.; Zhang, W.-P.; Dong, Y.-L.; Lu, J. The Adenosine Deaminase Gene Polymorphism Is Associated with Chronic Heart Failure Risk in Chinese. Int. J. Mol. Sci. 2014, 15, 15259-15271.

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