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Int. J. Mol. Sci. 2014, 15(7), 12885-12894; doi:10.3390/ijms150712885
Article

Effects of β2-Adrenergic Receptor Gene Polymorphisms on Ritodrine Therapy in Pregnant Women with Preterm Labor: Prospective Follow-Up Study

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1,2
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3,*  and 1,*
1 College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea 2 College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea 3 Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul 158-710, Korea
* Authors to whom correspondence should be addressed.
Received: 27 May 2014 / Revised: 25 June 2014 / Accepted: 11 July 2014 / Published: 21 July 2014
(This article belongs to the collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract

This study aimed to evaluate the effects of β2-adrenergic receptor (ADRB2) gene polymorphisms on ritodrine therapy outcomes in patients with preterm labor. Genotyping analysis of ADRB2 gene (rs1042713, rs1042714, rs1042717, rs1042718, and rs1042719) was performed on 137 patients with preterm labor. Survival analysis was conducted for the effects of SNPs on the median time to delivery as a primary outcome. The median time to delivery in the study patients was 349.3 h. Gestational age at admission and modified Bishop scores revealed significant effects on time to delivery (p < 0.001). Among studied SNPs, rs1042717 and rs1042718 showed linkage disequilibrium in this population, and their effects on time to delivery were marginally significant (p < 0.1). Patients with variant-homozygotes in the rs1042713 showed considerably shortened time to delivery compared to wild-allele carriers. The rs1042719 polymorphism significantly affected time to delivery in both univariate and multivariate analysis; the GC and CC carriers showed 64% decrease in time to delivery compared to the wild-type homozygote carriers. Based on the results, it was concluded that the gene polymorphisms of ADRB2 could affect ritodrine therapy in patients with preterm labor. However, given the single-center and the relatively small sample size, our hypothesis requires further independent validation using multi-center and large sample size.
Keywords: ritodrine; preterm labor; β2-adrenergic receptor gene; single nucleotide polymorphism ritodrine; preterm labor; β2-adrenergic receptor gene; single nucleotide polymorphism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Park, J.Y.; Lee, N.R.; Lee, K.E.; Park, S.; Kim, Y.J.; Gwak, H.S. Effects of β2-Adrenergic Receptor Gene Polymorphisms on Ritodrine Therapy in Pregnant Women with Preterm Labor: Prospective Follow-Up Study. Int. J. Mol. Sci. 2014, 15, 12885-12894.

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