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Int. J. Mol. Sci. 2014, 15(7), 12258-12269; doi:10.3390/ijms150712258

Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects

1
Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China
2
Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 8 May 2014 / Revised: 9 June 2014 / Accepted: 19 June 2014 / Published: 10 July 2014
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract

Signal transducer and activator of transcription 3 (STAT3) plays an important role in energy metabolism. Here we explore whether STAT3 common variations influence risks of obesity and other metabolic disorders in a Chinese Han population. Two tagging single nucleotide polymorphisms (tagSNPs), rs1053005 and rs957970, were used to capture the common variations of STAT3. Relationships between genotypes and obesity, body mass index, plasma triglyceride and other metabolic diseases related parameters were analyzed for association study in 1742 subjects. Generalized linear model and logistic regression model were used for quantitative data analysis and case-control study, respectively. rs1053005 was significantly associated with body mass index and waist circumference (p = 0.013 and p = 0.02, respectively). rs957970 was significantly associated with plasma level of triglyceride (p = 0.007). GG genotype at rs1053005 had lower risks of both general obesity and central obesity (OR = 0.40, p = 0.034; OR = 0.42, p = 0.007, respectively) compared with AA genotype. CT genotype at rs957970 had a higher risk of hypertriglyceridemia (OR = 1.43, p = 0.015) compared with TT genotype. Neither of the two SNPs was associated with othermetabolic diseases related parameters. Our observations indicated that common variations of STAT3 could significantly affect the risk of obesity and hypertriglyceridemia in Chinese Han population. View Full-Text
Keywords: obesity; body-mass index; hypertriglyceridemia; genetic susceptibility; signal transducer and activator of transcription 3 obesity; body-mass index; hypertriglyceridemia; genetic susceptibility; signal transducer and activator of transcription 3
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ma, Z.; Wang, G.; Chen, X.; Ou, Z.; Zou, F. Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects. Int. J. Mol. Sci. 2014, 15, 12258-12269.

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