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Int. J. Mol. Sci. 2014, 15(5), 8808-8820; doi:10.3390/ijms15058808
Communication

Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues

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Received: 1 March 2014; in revised form: 31 March 2014 / Accepted: 17 April 2014 / Published: 16 May 2014
(This article belongs to the Special Issue Molecular Science for Drug Development and Biomedicine)
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Abstract: A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification.
Keywords: anti-inflammatory; caffeic acid amides; synthesis; pharmacophore; target predication anti-inflammatory; caffeic acid amides; synthesis; pharmacophore; target predication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, Z.; Fu, J.; Shan, L.; Sun, Q.; Zhang, W. Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues. Int. J. Mol. Sci. 2014, 15, 8808-8820.

AMA Style

Liu Z, Fu J, Shan L, Sun Q, Zhang W. Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues. International Journal of Molecular Sciences. 2014; 15(5):8808-8820.

Chicago/Turabian Style

Liu, Zhiqian; Fu, Jianjun; Shan, Lei; Sun, Qingyan; Zhang, Weidong. 2014. "Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues." Int. J. Mol. Sci. 15, no. 5: 8808-8820.



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