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Int. J. Mol. Sci. 2014, 15(5), 8138-8152; doi:10.3390/ijms15058138
Review

Rationale for the Use of Upfront Whole Brain Irradiation in Patients with Brain Metastases from Breast Cancer

1,11,* , 2,11
, 3,11
, 4,11
, 5,11
, 6,11
, 7,11
, 8,11
, 9,11
 and 10,11
1 Department of Radiation Oncology, Institut Paoli Calmettes, Marseille 13009, France 2 Department of Radiation Oncology and INSERM U896, CRLC Val d'Aurelle, Montpellier 34000, France 3 Breast Unit, Department of Medical Oncology, Oscar Lambret Center, Lille Cedex 59020, France 4 Multidisciplinary Oncology and Therapeutic Innovations Department & Centre Investigation Clinique, Aix Marseille University—Assistance Publique Hôpitaux de Marseille, Marseille 13011, France 5 Department of Neurology, Hopital Avicenne, Assistance Publique des Hopitaux de Paris, Bobigny 93000, France 6 Department of Medical Oncology, Institut Paoli Calmettes, Marseille 13009, France 7 Department of Radiation Oncology and Department of Neuro-Oncology, Pitié-Salpétrière Hospital, Paris 75013, France 8 Department of Radiation Oncology, Institut Gustave Roussy University Hospital, Villejuif 94805, France 9 Department of Medical Oncology, GH Pitié-Salpêtrière, Université Paris 6, Paris 75013, France 10 Department of Neurosurgery, Hopital La Timone, Assistance Publique-Hôpitaux de Marseille and INSERM UMR 911, Marseille 13006, France 11 Groupe de Réflexion sur la Prise en Charge des MétAstases Cérébrales (GRPCMaC), Marseille 13009, France 
* Author to whom correspondence should be addressed.
Received: 31 March 2014 / Revised: 22 April 2014 / Accepted: 25 April 2014 / Published: 8 May 2014
(This article belongs to the Special Issue Brain Metastasis 2014)
View Full-Text   |   Download PDF [214 KB, uploaded 19 June 2014]

Abstract

Breast cancer is the second most common cause of brain metastases and deserves particular attention in relation to current prolonged survival of patients with metastatic disease. Advances in both systemic therapies and brain local treatments (surgery and stereotactic radiosurgery) have led to a reappraisal of brain metastases management. With respect to this, the literature review presented here was conducted in an attempt to collect medical evidence-based data on the use of whole-brain radiotherapy for the treatment of brain metastases from breast cancer. In addition, this study discusses here the potential differences in outcomes between patients with brain metastases from breast cancer and those with brain metastases from other primary malignancies and the potential implications within a treatment strategy.
Keywords: whole brain radiation therapy; breast cancer; brain metastases; controlled extra-cranial disease; overall survival whole brain radiation therapy; breast cancer; brain metastases; controlled extra-cranial disease; overall survival
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tallet, A.V.; Azria, D.; Rhun, E.L.; Barlesi, F.; Carpentier, A.F.; Gonçalves, A.; Taillibert, S.; Dhermain, F.; Spano, J.-P.; Metellus, P. Rationale for the Use of Upfront Whole Brain Irradiation in Patients with Brain Metastases from Breast Cancer. Int. J. Mol. Sci. 2014, 15, 8138-8152.

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