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Int. J. Mol. Sci. 2014, 15(5), 7958-7973; doi:10.3390/ijms15057958
Review

Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility

* ,
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Received: 3 April 2014; in revised form: 11 April 2014 / Accepted: 21 April 2014 / Published: 7 May 2014
(This article belongs to the Special Issue Genetic Susceptibility to Carcinogen-Induced Cancer)
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Abstract: Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells; however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.
Keywords: gastric cancer; mucin 1; Helicobacter pylori; genome-wide association study; single nucleotide polymorphism; cancer susceptibility gene gastric cancer; mucin 1; Helicobacter pylori; genome-wide association study; single nucleotide polymorphism; cancer susceptibility gene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Saeki, N.; Sakamoto, H.; Yoshida, T. Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility. Int. J. Mol. Sci. 2014, 15, 7958-7973.

AMA Style

Saeki N, Sakamoto H, Yoshida T. Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility. International Journal of Molecular Sciences. 2014; 15(5):7958-7973.

Chicago/Turabian Style

Saeki, Norihisa; Sakamoto, Hiromi; Yoshida, Teruhiko. 2014. "Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility." Int. J. Mol. Sci. 15, no. 5: 7958-7973.


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