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Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility
AbstractGastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells; however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.
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Saeki, N.; Sakamoto, H.; Yoshida, T. Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility. Int. J. Mol. Sci. 2014, 15, 7958-7973.View more citation formats
Saeki N, Sakamoto H, Yoshida T. Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility. International Journal of Molecular Sciences. 2014; 15(5):7958-7973.Chicago/Turabian Style
Saeki, Norihisa; Sakamoto, Hiromi; Yoshida, Teruhiko. 2014. "Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility." Int. J. Mol. Sci. 15, no. 5: 7958-7973.