Tug of War between Survival and Death: Exploring ATM Function in Cancer
AbstractAtaxia-telangiectasia mutated (ATM) kinase is a one of the main guardian of genome stability and plays a central role in the DNA damage response (DDR). The deregulation of these pathways is strongly linked to cancer initiation and progression as well as to the development of therapeutic approaches. These observations, along with reports that identify ATM loss of function as an event that may promote tumor initiation and progression, point to ATM as a bona fide tumor suppressor. The identification of ATM as a positive modulator of several signalling networks that sustain tumorigenesis, including oxidative stress, hypoxia, receptor tyrosine kinase and AKT serine-threonine kinase activation, raise the question of whether ATM function in cancer may be more complex. This review aims to give a complete overview on the work of several labs that links ATM to the control of the balance between cell survival, proliferation and death in cancer. View Full-Text
Share & Cite This Article
Stagni, V.; Oropallo, V.; Fianco, G.; Antonelli, M.; Cinà, I.; Barilà, D. Tug of War between Survival and Death: Exploring ATM Function in Cancer. Int. J. Mol. Sci. 2014, 15, 5388-5409.
Stagni V, Oropallo V, Fianco G, Antonelli M, Cinà I, Barilà D. Tug of War between Survival and Death: Exploring ATM Function in Cancer. International Journal of Molecular Sciences. 2014; 15(4):5388-5409.Chicago/Turabian Style
Stagni, Venturina; Oropallo, Veronica; Fianco, Giulia; Antonelli, Martina; Cinà, Irene; Barilà, Daniela. 2014. "Tug of War between Survival and Death: Exploring ATM Function in Cancer." Int. J. Mol. Sci. 15, no. 4: 5388-5409.