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Int. J. Mol. Sci. 2014, 15(2), 2712-2721; doi:10.3390/ijms15022712
Article

E26 Transformation-Specific-1 (ETS1) and WDFY Family Member 4 (WDFY4) Polymorphisms in Chinese Patients with Rheumatoid Arthritis

1
,
2
,
3
,
3
 and
3,4,*
1 Department of Ophthalmology, Affiliated Hospital of Suzhou University, Changzhou No.4 People's Hospital, Changzhou 213001, Jiangsu, China 2 Department of Rheumatology, the Second Affiliated Hospital of Soochow University, Suzhou 215002, Jiangsu, China 3 Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, Jiangsu, China 4 Central Laboratory, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, Jiangsu, China
* Author to whom correspondence should be addressed.
Received: 5 January 2014 / Revised: 30 January 2014 / Accepted: 11 February 2014 / Published: 17 February 2014
(This article belongs to the collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract

E26 transformation-specific-1 (ETS1) and WDFY family member 4 (WDFY4) are closely related with systemic lupus erythematosus. We hypothesized that ETS1 and WDFY4 polymorphisms may contribute to rheumatoid arthritis (RA) susceptibility. We studied ETS1 rs1128334 G/A and WDFY4 rs7097397 A/G gene polymorphisms in 329 patients with RA and 697 controls in a Chinese population. Genotyping was done using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. When the WDFY4 rs7097397 AA homozygote genotype was used as the reference group, the AG genotype was associated with a significantly increased risk for RA. In the dominant model, when the WDFY4 rs7097397 AA homozygote genotype was used as the reference group, the AG/GG genotypes were associated with a significant increased susceptibility to RA. In stratification analyses, a significantly increased risk for RA associated with the WDFY4 rs7097397 AG genotype was evident among female patients, younger patients, C-reactive protein (CRP) negative patients and both anti-cyclic citrullinated peptide antibody (ACPA) positive patients and negative patients compared with the WDFY4 rs7097397 AA genotype. These findings suggested that WDFY4 rs7097397 A/G may be associated with the risk of RA, especially among younger, female patients, CRP-negative patients and both ACPA positive and negative patients. However, our results were obtained from a moderate-sized sample, and therefore this is a preliminary conclusion. To confirm these findings, validation by a larger study from a more diverse ethnic population is needed.
Keywords: ETS1; WDFY4; polymorphisms; rheumatoid arthritis; molecular epidemiology ETS1; WDFY4; polymorphisms; rheumatoid arthritis; molecular epidemiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, Y.; Bo, L.; Zhang, H.; Zhuang, C.; Liu, R. E26 Transformation-Specific-1 (ETS1) and WDFY Family Member 4 (WDFY4) Polymorphisms in Chinese Patients with Rheumatoid Arthritis. Int. J. Mol. Sci. 2014, 15, 2712-2721.

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