Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2014, 15(2), 2646-2659; doi:10.3390/ijms15022646
Article

Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population

1,†
, 2,†
, 1,†
, 1
, 1
, 1
, 1
, 1,*  and 1,3,*
Received: 1 January 2014; in revised form: 15 January 2014 / Accepted: 22 January 2014 / Published: 14 February 2014
(This article belongs to the collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
View Full-Text   |   Download PDF [341 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development.
Keywords: mitochondria; haplogroup; osteoarthritis; copy number mitochondria; haplogroup; osteoarthritis; copy number
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Fang, H.; Liu, X.; Shen, L.; Li, F.; Liu, Y.; Chi, H.; Miao, H.; Lu, J.; Bai, Y. Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population. Int. J. Mol. Sci. 2014, 15, 2646-2659.

AMA Style

Fang H, Liu X, Shen L, Li F, Liu Y, Chi H, Miao H, Lu J, Bai Y. Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population. International Journal of Molecular Sciences. 2014; 15(2):2646-2659.

Chicago/Turabian Style

Fang, Hezhi; Liu, Xinwei; Shen, Lijun; Li, Fengjie; Liu, Yihong; Chi, Hongbo; Miao, Huikai; Lu, Jianxin; Bai, Yidong. 2014. "Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population." Int. J. Mol. Sci. 15, no. 2: 2646-2659.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert