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Int. J. Mol. Sci. 2014, 15(12), 22786-22800; doi:10.3390/ijms151222786

Enhanced in Vivo Delivery of 5-Fluorouracil by Ethosomal Gels in Rabbit Ear Hypertrophic Scar Model

1
Department of Human Anatomy, Histology and Embryology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025,China
2
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
3
Department of Dermatology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
4
National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
5
Department of Otolaryngology-Head and Neck Surgery, the Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China
6
Department of Orthopaedic Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 31 August 2014 / Revised: 22 October 2014 / Accepted: 10 November 2014 / Published: 9 December 2014
(This article belongs to the Section Biomaterial Sciences)
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Abstract

Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stability assay in vitro revealed that 5-FU EGs stored for a period of 30 days at 4 ± 1 °C had a better size stability than that at 25 ± 1 °C. Furthermore, using confocal laser scanning microscopy, EGs labeled with Rhodamine 6 G penetrated into the deep dermis of the hypertrophic scar within 24 h in the rabbit ear hypertrophic model suggested that the EGs were an optional delivery carrier through scar tissues. In addition, the value of the Scar Elevation Index (SEI) of 5-FU EGs group in the rabbit ear scar model was lower than that of 5-FU Phosphate Buffered Saline gel and Control groups. To conclude, these results suggest that EGs delivery system loaded 5-fluorouracil is a perfect candidate drug for hypertrophic scars therapy in future. View Full-Text
Keywords: drug delivery; ethosome; 5-fluorouracil; gel; hypertrophic scars penetration drug delivery; ethosome; 5-fluorouracil; gel; hypertrophic scars penetration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wo, Y.; Zhang, Z.; Zhang, Y.; Zhang, Z.; Wang, K.; Mao, X.; Su, W.; Li, K.; Cui, D.; Chen, J. Enhanced in Vivo Delivery of 5-Fluorouracil by Ethosomal Gels in Rabbit Ear Hypertrophic Scar Model. Int. J. Mol. Sci. 2014, 15, 22786-22800.

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