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Int. J. Mol. Sci. 2014, 15(12), 22483-22491; doi:10.3390/ijms151222483

Cytotoxicity Evaluation of a New Set of 2-Aminobenzo[de]iso-quinoline-1,3-diones

1
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
2
Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki, Cairo 12622, Egypt
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 3 September 2014 / Revised: 13 October 2014 / Accepted: 2 December 2014 / Published: 4 December 2014
(This article belongs to the Section Molecular Toxicology)
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Abstract

A new series of 2-amino-benzo[de]isoquinoline-1,3-diones was synthesized and fully characterized in our previous paper. Here, their cytotoxic effects have been evaluated in vitro in relation to colon HCT-116, hepatocellular Hep-G2 and breast MCF-7 cancer cell lines, using a crystal violet viability assay. The IC50-values of the target compounds are reported in µg/mL, using doxorubicin as a reference drug. The findings revealed that compounds 14, 15, 16, 21 and 22 had significant cytotoxic effects against HCT-116, MCF-7 and Hep-G2 cell lines. Their IC50 values ranged between 1.3 and 8.3 μg/mL in relation to doxorubicin (IC50 ≈ 0.45–0.89 μg/mL). Therefore, these compounds could be used as templates for furthering the development and design of more potent antitumor agents through structural modification. View Full-Text
Keywords: cytotoxicity; HCT-116; Hep-G2; aminobenzo[de]isoquinoline-1,3-diones; doxorubicin cytotoxicity; HCT-116; Hep-G2; aminobenzo[de]isoquinoline-1,3-diones; doxorubicin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Al-Salahi, R.; Alswaidan, I.; Marzouk, M. Cytotoxicity Evaluation of a New Set of 2-Aminobenzo[de]iso-quinoline-1,3-diones. Int. J. Mol. Sci. 2014, 15, 22483-22491.

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