Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction
AbstractAcute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Zhong, J.; He, Y.; Chen, W.; Shui, X.; Chen, C.; Lei, W. Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. Int. J. Mol. Sci. 2014, 15, 20355-20364.
Zhong J, He Y, Chen W, Shui X, Chen C, Lei W. Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. International Journal of Molecular Sciences. 2014; 15(11):20355-20364.Chicago/Turabian Style
Zhong, Jianfeng; He, Yuan; Chen, Wenjiang; Shui, Xiaorong; Chen, Can; Lei, Wei. 2014. "Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction." Int. J. Mol. Sci. 15, no. 11: 20355-20364.