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Int. J. Mol. Sci. 2014, 15(11), 20355-20364; doi:10.3390/ijms151120355

Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

1,†
,
2,†
,
1
,
3
,
1,2,* and 1,2,*
1
Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China
2
Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China
3
Laboratory of Vascular Surgery, Guangdong Medical College, Zhanjiang 524001, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 June 2014 / Revised: 20 October 2014 / Accepted: 24 October 2014 / Published: 6 November 2014
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI. View Full-Text
Keywords: acute myocardial infarction; biomarkers; diagnosis; miRNA; miR-19a acute myocardial infarction; biomarkers; diagnosis; miRNA; miR-19a
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhong, J.; He, Y.; Chen, W.; Shui, X.; Chen, C.; Lei, W. Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. Int. J. Mol. Sci. 2014, 15, 20355-20364.

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