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Int. J. Mol. Sci. 2014, 15(11), 20045-20053; doi:10.3390/ijms151120045

Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.

1
Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea
2
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon 323-833, Korea
*
Author to whom correspondence should be addressed.
Received: 11 September 2014 / Revised: 21 October 2014 / Accepted: 23 October 2014 / Published: 4 November 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 μM) against six human cancer cell lines. View Full-Text
Keywords: sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, Y.-J.; Lee, J.-W.; Lee, D.-G.; Lee, H.-S.; Kang, J.S.; Yun, J. Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.. Int. J. Mol. Sci. 2014, 15, 20045-20053.

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