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Int. J. Mol. Sci. 2014, 15(11), 19938-19951; doi:10.3390/ijms151119938

Advances in the Function and Regulation of Hydrogenase in the Cyanobacterium Synechocystis PCC6803

UMR8221, CEA, CNRS, University of Paris XI, Institute of Biology and Technology Saclay, Laboratory of Biology and Biotechnology of Cyanobacteria, CEA-Saclay, Gif sur Yvette 91 191, France
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Received: 11 September 2014 / Revised: 15 October 2014 / Accepted: 21 October 2014 / Published: 31 October 2014
(This article belongs to the Special Issue Photosynthesis and Biological Hydrogen Production)
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Abstract

In order to use cyanobacteria for the biological production of hydrogen, it is important to thoroughly study the function and the regulation of the hydrogen-production machine in order to better understand its role in the global cell metabolism and identify bottlenecks limiting H2 production. Most of the recent advances in our understanding of the bidirectional [Ni-Fe] hydrogenase (Hox) came from investigations performed in the widely-used model cyanobacterium Synechocystis PCC6803 where Hox is the sole enzyme capable of combining electrons with protons to produce H2 under specific conditions. Recent findings suggested that the Hox enzyme can receive electrons from not only NAD(P)H as usually shown, but also, or even preferentially, from ferredoxin. Furthermore, plasmid-encoded functions and glutathionylation (the formation of a mixed-disulfide between the cysteines residues of a protein and the cysteine residue of glutathione) are proposed as possible new players in the function and regulation of hydrogen production. View Full-Text
Keywords: hydrogen; bioproduction; cyanobacteria; oxidative stress; regulation; cysteine oxidation; sugar stress; electron transport; ferredoxin hydrogen; bioproduction; cyanobacteria; oxidative stress; regulation; cysteine oxidation; sugar stress; electron transport; ferredoxin
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MDPI and ACS Style

Cassier-Chauvat, C.; Veaudor, T.; Chauvat, F. Advances in the Function and Regulation of Hydrogenase in the Cyanobacterium Synechocystis PCC6803. Int. J. Mol. Sci. 2014, 15, 19938-19951.

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