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Int. J. Mol. Sci. 2014, 15(10), 19239-19252; doi:10.3390/ijms151019239

Heparin Assisted Photochemical Synthesis of Gold Nanoparticles and Their Performance as SERS Substrates

1
Grupo de Espectroscopia de Materiales Avanzados y Nanoestructurados (GEMANA), Centro de Investigaciones en Óptica, A.C. Loma del Bosque 115, León, Guanajuato, C.P. 37150, Mexico
2
Centro de Investigaciones en Óptica, A.C., Loma del Bosque 115, León, Guanajuato, C.P. 37150, Mexico
*
Author to whom correspondence should be addressed.
Received: 2 September 2014 / Revised: 30 September 2014 / Accepted: 13 October 2014 / Published: 23 October 2014
(This article belongs to the Special Issue Bioactive Nanoparticles 2014)
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Abstract

Reactive and pharmaceutical-grade heparins were used as biologically compatible reducing and stabilizing agents to photochemically synthesize colloidal gold nanoparticles. Aggregates and anisotropic shapes were obtained photochemically under UV black-light lamp irradiation (λ = 366 nm). Heparin-functionalized gold nanoparticles were characterized by Scanning Electron Microscopy and UV-Vis spectroscopy. The negatively charged colloids were used for the Surface Enhanced Raman Spectroscopy (SERS) analysis of differently charged analytes (dyes). Measurements of pH were taken to inspect how the acidity of the medium affects the colloid-analyte interaction. SERS spectra were taken by mixing the dyes and the colloidal solutions without further functionalization or addition of any aggregating agent. View Full-Text
Keywords: heparin; gold nanoparticles; photochemistry; SERS; organic dyes heparin; gold nanoparticles; photochemistry; SERS; organic dyes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

del Pilar Rodríguez-Torres, M.; Díaz-Torres, L.A.; Romero-Servin, S. Heparin Assisted Photochemical Synthesis of Gold Nanoparticles and Their Performance as SERS Substrates. Int. J. Mol. Sci. 2014, 15, 19239-19252.

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