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Int. J. Mol. Sci. 2014, 15(10), 18747-18761; doi:10.3390/ijms151018747

Association between the Hypomethylation of Osteopontin and Integrin β3 Promoters and Vascular Smooth Muscle Cell Phenotype Switching in Great Saphenous Varicose Veins

Department of Vascular and Thyroid Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
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Received: 5 July 2014 / Revised: 28 September 2014 / Accepted: 9 October 2014 / Published: 17 October 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Lower extremity varicose veins are a common condition in vascular surgery and proliferation of vascular smooth muscle cells (VSMCs) in the intima is a significant pathological feature of varicosity. However, the pathogenesis of varicose veins is not fully understood. Osteopontin (OPN) could promote the migration and adhesion of VSMCs through the cell surface receptor integrin β3 and the cooperation of OPN and integrin β3 is involved in many vascular diseases. However, the role of OPN and integrin β3 in varicosity remains unclear. In the current study, we found that the methylation levels in the promoter regions of OPN and integrin β3 genes in the VSMCs of varicose veins are reduced and the protein expression of OPN and integrin β3 are increased, compared with normal veins. Furthermore, it was observed that VSMCs in the neointima of varicose veins were transformed into the synthetic phenotype. Collectively, hypomethylation of the promoter regions for OPN and integrin β3 genes may increase the expression of these genes in varicosity, which is closely related to VSMC phenotype switching. Hypomethylation of the promoter regions for OPN and integrin β3 genes may be a key factor in the pathogenesis of varicosity. View Full-Text
Keywords: varicosity; vascular smooth muscle cells; phenotype switching; osteopontin; integrin β3; DNA methylation varicosity; vascular smooth muscle cells; phenotype switching; osteopontin; integrin β3; DNA methylation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jiang, H.; Lun, Y.; Wu, X.; Xia, Q.; Zhang, X.; Xin, S.; Zhang, J. Association between the Hypomethylation of Osteopontin and Integrin β3 Promoters and Vascular Smooth Muscle Cell Phenotype Switching in Great Saphenous Varicose Veins. Int. J. Mol. Sci. 2014, 15, 18747-18761.

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