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Int. J. Mol. Sci. 2014, 15(10), 17411-17441; doi:10.3390/ijms151017411

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

1
Central Laboratory, Navy General Hospital, Beijing 100048, China
2
National Key Laboratory of Biotherapy and Cancer Research (NKLB), West China Hospital and Medical School, Sichuan University, Chengdu 610041, China
3
Department of Dermatology, University of Colorado at Denver, Anschutz Medical Center, Aurora, CO 80025, USA
*
Author to whom correspondence should be addressed.
Received: 4 August 2014 / Revised: 8 September 2014 / Accepted: 16 September 2014 / Published: 29 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the discovery, characterization, molecular structure, diverse biological functions and regulatory mechanisms of CD147 in human physiological and pathological processes. In particular, recent studies have demonstrated the potential application of CD147 not only as a phenotypic marker of activated regulatory T cells but also as a potential diagnostic marker for early-stage disease. Moreover, CD147 is recognized as an effective therapeutic target for hepatocellular carcinoma (HCC) and other cancers, and exciting clinical progress has been made in HCC treatment using CD147-directed monoclonal antibodies. View Full-Text
Keywords: CD147; EMMPRIN; biological function; pathogenesis; diagnostic biomarkers; therapeutic target; matrix metalloproteinases (MMPs) CD147; EMMPRIN; biological function; pathogenesis; diagnostic biomarkers; therapeutic target; matrix metalloproteinases (MMPs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xiong, L.; Edwards, C.K., III; Zhou, L. The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature. Int. J. Mol. Sci. 2014, 15, 17411-17441.

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