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Int. J. Mol. Sci. 2014, 15(1), 1026-1039; doi:10.3390/ijms15011026
Article

Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C

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1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan 2 Shiodome Medical Examination Clinic, Tokyo 105-0013, Japan 3 Anzai Medical Co., Ltd., Tokyo 141-0033, Japan 4 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kawasaki 214-8525, Kanagawa, Japan 5 Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakabadai Hospital, Sapporo 062-0052, Hokkaido, Japan
* Author to whom correspondence should be addressed.
Received: 6 November 2013 / Revised: 24 December 2013 / Accepted: 27 December 2013 / Published: 14 January 2014
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
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Abstract

Aims: The present study evaluated the utility of xenon computed tomography (Xe-CT) as a noninvasive diagnostic procedure for the measurement of hepatic tissue blood flow (TBF) in patients with nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C (CH-C). Methods: Xe-CT was performed in 93 patients with NAFLD and in 109 patients with CH-C. Subjects were classified into one of three groups, based on fibrosis stage: group 1, no bridging fibrosis; group 2, bridging fibrosis; and group 3, liver cirrhosis. Correlations between hepatic TBFs in each fibrosis stage were examined. Results: In group 1, portal venous TBF (PVTBF), hepatic arterial (HATBF), and total hepatic TBF (THTBF) were significantly lower in patients with in nonalcoholic steatohepatitis (NASH) than in those with CH-C (p < 0.001, p < 0.05, p < 0.001, respectively). In group 2, PVTBF and THTBF were significantly lower in patients with in NASH than in those with CH-C (p < 0.001, p < 0.05, respectively). In group 3, hepatic TBFs were not significantly different when comparing patients with NASH and those with CH-C. Conclusions: PVTBF decreased due to fat infiltration. Therefore, hemodynamic changes occur relatively earlier in NAFLD than in CH-C. Patients with NASH should be monitored carefully for portal hypertensive complications in the early fibrosis stage.
Keywords: nonalcoholic steatohepatitis; chronic hepatitis C; hepatic tissue blood flow; Xe computed tomography nonalcoholic steatohepatitis; chronic hepatitis C; hepatic tissue blood flow; Xe computed tomography
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shigefuku, R.; Takahashi, H.; Kato, M.; Yoshida, Y.; Suetani, K.; Noguchi, Y.; Hatsugai, M.; Nakahara, K.; Ikeda, H.; Kobayashi, M.; Matsunaga, K.; Matsumoto, N.; Okuse, C.; Itoh, F.; Maeyama, S.; Sase, S.; Suzuki, M. Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C. Int. J. Mol. Sci. 2014, 15, 1026-1039.

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