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Molecular Interactions in the Development of Brain Metastases
Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 23 June 2013; in revised form: 9 August 2013 / Accepted: 9 August 2013 / Published: 20 August 2013
Abstract: Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
Keywords: CNS metastasis; metastatic cascade; vascular co-option; dormancy
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MDPI and ACS Style
Martinez, N.; Boire, A.; DeAngelis, L.M. Molecular Interactions in the Development of Brain Metastases. Int. J. Mol. Sci. 2013, 14, 17157-17167.
Martinez N, Boire A, DeAngelis LM. Molecular Interactions in the Development of Brain Metastases. International Journal of Molecular Sciences. 2013; 14(8):17157-17167.
Martinez, Nina; Boire, Adrienne; DeAngelis, Lisa M. 2013. "Molecular Interactions in the Development of Brain Metastases." Int. J. Mol. Sci. 14, no. 8: 17157-17167.