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Int. J. Mol. Sci. 2013, 14(8), 17157-17167; doi:10.3390/ijms140817157

Molecular Interactions in the Development of Brain Metastases

Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 23 June 2013 / Revised: 9 August 2013 / Accepted: 9 August 2013 / Published: 20 August 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)

Abstract

Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
Keywords: CNS metastasis; metastatic cascade; vascular co-option; dormancy CNS metastasis; metastatic cascade; vascular co-option; dormancy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Martinez, N.; Boire, A.; DeAngelis, L.M. Molecular Interactions in the Development of Brain Metastases. Int. J. Mol. Sci. 2013, 14, 17157-17167.

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