Int. J. Mol. Sci. 2013, 14(8), 17157-17167; doi:10.3390/ijms140817157
Review

Molecular Interactions in the Development of Brain Metastases

Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 23 June 2013; in revised form: 9 August 2013 / Accepted: 9 August 2013 / Published: 20 August 2013
(This article belongs to the Section Molecular Pathology)
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Abstract: Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
Keywords: CNS metastasis; metastatic cascade; vascular co-option; dormancy

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MDPI and ACS Style

Martinez, N.; Boire, A.; DeAngelis, L.M. Molecular Interactions in the Development of Brain Metastases. Int. J. Mol. Sci. 2013, 14, 17157-17167.

AMA Style

Martinez N, Boire A, DeAngelis LM. Molecular Interactions in the Development of Brain Metastases. International Journal of Molecular Sciences. 2013; 14(8):17157-17167.

Chicago/Turabian Style

Martinez, Nina; Boire, Adrienne; DeAngelis, Lisa M. 2013. "Molecular Interactions in the Development of Brain Metastases." Int. J. Mol. Sci. 14, no. 8: 17157-17167.

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