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Int. J. Mol. Sci. 2013, 14(8), 17157-17167; doi:10.3390/ijms140817157
Review

Molecular Interactions in the Development of Brain Metastases

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Received: 23 June 2013; in revised form: 9 August 2013 / Accepted: 9 August 2013 / Published: 20 August 2013
(This article belongs to the Section Molecular Pathology)
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Abstract: Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
Keywords: CNS metastasis; metastatic cascade; vascular co-option; dormancy CNS metastasis; metastatic cascade; vascular co-option; dormancy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Martinez, N.; Boire, A.; DeAngelis, L.M. Molecular Interactions in the Development of Brain Metastases. Int. J. Mol. Sci. 2013, 14, 17157-17167.

AMA Style

Martinez N, Boire A, DeAngelis LM. Molecular Interactions in the Development of Brain Metastases. International Journal of Molecular Sciences. 2013; 14(8):17157-17167.

Chicago/Turabian Style

Martinez, Nina; Boire, Adrienne; DeAngelis, Lisa M. 2013. "Molecular Interactions in the Development of Brain Metastases." Int. J. Mol. Sci. 14, no. 8: 17157-17167.


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