Next Article in Journal
Protein Structures among Bio-Ethanol Co-Products and Its Relationships with Ruminal and Intestinal Availability of Protein in Dairy Cattle
Next Article in Special Issue
Preparation and Characterization of Nanoliposomes Entrapping Medium-Chain Fatty Acids and Vitamin C by Lyophilization
Previous Article in Journal
Endogenous Protease Nexin-1 Protects against Cerebral Ischemia
Previous Article in Special Issue
Galactosylated Chitosan Oligosaccharide Nanoparticles for Hepatocellular Carcinoma Cell-Targeted Delivery of Adenosine Triphosphate
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(8), 16732-16801; doi:10.3390/ijms140816732

The Effects of Nanomaterials as Endocrine Disruptors

Institute of Public Health, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Roma 00168, Italy
*
Author to whom correspondence should be addressed.
Received: 30 May 2013 / Revised: 8 July 2013 / Accepted: 25 July 2013 / Published: 14 August 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2013)
View Full-Text   |   Download PDF [1177 KB, uploaded 19 June 2014]   |  

Abstract

In recent years, nanoparticles have been increasingly used in several industrial, consumer and medical applications because of their unique physico-chemical properties. However, in vitro and in vivo studies have demonstrated that these properties are also closely associated with detrimental health effects. There is a serious lack of information on the potential nanoparticle hazard to human health, particularly on their possible toxic effects on the endocrine system. This topic is of primary importance since the disruption of endocrine functions is associated with severe adverse effects on human health. Consequently, in order to gather information on the hazardous effects of nanoparticles on endocrine organs, we reviewed the data available in the literature regarding the endocrine effects of in vitro and in vivo exposure to different types of nanoparticles. Our aim was to understand the potential endocrine disrupting risks posed by nanoparticles, to assess their underlying mechanisms of action and identify areas in which further investigation is needed in order to obtain a deeper understanding of the role of nanoparticles as endocrine disruptors. Current data support the notion that different types of nanoparticles are capable of altering the normal and physiological activity of the endocrine system. However, a critical evaluation of these findings suggests the need to interpret these results with caution since information on potential endocrine interactions and the toxicity of nanoparticles is quite limited.
Keywords: nanoparticles; endocrine system; endocrine disruptors; health effects; humans; in vitro studies; in vivo studies; animal; cell lines; invertebrates nanoparticles; endocrine system; endocrine disruptors; health effects; humans; in vitro studies; in vivo studies; animal; cell lines; invertebrates
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Iavicoli, I.; Fontana, L.; Leso, V.; Bergamaschi, A. The Effects of Nanomaterials as Endocrine Disruptors. Int. J. Mol. Sci. 2013, 14, 16732-16801.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top