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Int. J. Mol. Sci. 2013, 14(8), 16402-16413; doi:10.3390/ijms140816402
Brief Report

Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study

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, 3,4,5,†
 and 1,†,*
Received: 7 June 2013; in revised form: 29 July 2013 / Accepted: 30 July 2013 / Published: 8 August 2013
(This article belongs to the Special Issue Xenobiotic Metabolism)
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Abstract: We aimed to assess the association between the most common polymorphisms of cytochrome P450 (CYP) epoxygenases on the plasma levels of inflammatory markers in a population of healthy subjects. We also sought to determine whether CYP2C19*2 polymorphism is associated with the anti-inflammatory response to clopidogrel. In a population of 49 healthy young males, the baseline plasma levels of inflammatory markers including C-reactive protein, haptoglobin, orosomucoid acid, CD-40 were compared in carriers vs. non-carriers of the most frequent CYP epoxygenase polymorphisms: CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C8*2 and CYP2J2*7. Also, the variation of inflammatory markers from baseline to 7 days after administration of 75 mg per day of clopidogrel were compared in carriers vs. non-carriers of CYP2C19* allele and also in responders vs. hypo-responders to clopidogrel, determined by platelet reactivity tests. There was no significant association between epoxygenase polymorphisms and the baseline levels of inflammatory markers. Likewise, CYP2C19* allele was not associated with anti-inflammatory response to clopidogrel. Our findings did not support the notion that the genetic variations of CYP epoxygenases are associated with the level of inflammatory markers. Moreover, our results did not support the hypothesis that CYP2C19*2 polymorphism is associated with the variability in response to the anti-inflammatory properties of clopidogrel.
Keywords: inflammation; cytochrome P450; polymorphism; epoxyeicosatrienoic acids; clopidogrel; C-reactive protein; haptoglobin inflammation; cytochrome P450; polymorphism; epoxyeicosatrienoic acids; clopidogrel; C-reactive protein; haptoglobin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shahabi, P.; Siest, G.; Herbeth, B.; Lambert, D.; Masson, C.; Hulot, J.-S.; Bertil, S.; Gaussem, P.; Visvikis-Siest, S. Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study. Int. J. Mol. Sci. 2013, 14, 16402-16413.

AMA Style

Shahabi P, Siest G, Herbeth B, Lambert D, Masson C, Hulot J-S, Bertil S, Gaussem P, Visvikis-Siest S. Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study. International Journal of Molecular Sciences. 2013; 14(8):16402-16413.

Chicago/Turabian Style

Shahabi, Payman; Siest, Gérard; Herbeth, Bernard; Lambert, Daniel; Masson, Christine; Hulot, Jean-Sébastien; Bertil, Sébastien; Gaussem, Pascale; Visvikis-Siest, Sophie. 2013. "Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study." Int. J. Mol. Sci. 14, no. 8: 16402-16413.


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