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Int. J. Mol. Sci. 2013, 14(8), 15827-15837; doi:10.3390/ijms140815827

Cinnamtannin B-1 Regulates Cell Proliferation of Spinal Cord Astrocytes and Protects the Cell from Oxygen-Glucose-Serum Deprivation/Reoxygenation-Induced Apoptosis

1
Department of Orthopaedics, the First Affiliated Hospital of Harbin Medical University, NO.23 Youzheng St., Nangang District, Harbin 150001, China
2
Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, NO.37 Yiyuan Road, Nangang District, Harbin 150001, China
*
Author to whom correspondence should be addressed.
Received: 10 April 2013 / Revised: 28 June 2013 / Accepted: 28 June 2013 / Published: 30 July 2013
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Abstract

Astrocytes are important for protecting neurons in the central nervous system. It has been reported that some antioxidants could protect astrocytes from ischemia/reperfusion-induced dysfunction. Cinnamtannin B-1 is a naturally occurring A-type proanthocyanidin that exhibits anti-oxidant properties. In this study, we investigated the effects of cinnamtannin B-1 on spinal cord astrocytes. Astrocytes were subjected to oxygen-glucose-serum deprivation for eight hours followed by reoxygenation with or without cinnamtannin B-1. We found that cinnamtannin B-1 protected astrocytes from oxygen-glucose-serum deprivation and reoxygenation-induced apoptosis. Concurrently, cinnamtannin B-1 promoted the proliferation of astrocytes whereas the extracellular regulated protein kinase (ERK) inhibitor reversed this effect. The results indicated that cinnamtannin B-1 protects astrocytes from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis by promoting astrocyte proliferation via an ERK pathway. Therefore, as an anti-oxidant, cinnamtannin B-1 might provide extra benefit for astrocyte protection during ischemia/reperfusion in the central nervous system.
Keywords: astrocytes; cinnamtannin B-1; ischemia/reperfusion; apoptosis astrocytes; cinnamtannin B-1; ischemia/reperfusion; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chi, Z.; Ma, X.; Cui, G.; Li, M.; Li, F. Cinnamtannin B-1 Regulates Cell Proliferation of Spinal Cord Astrocytes and Protects the Cell from Oxygen-Glucose-Serum Deprivation/Reoxygenation-Induced Apoptosis. Int. J. Mol. Sci. 2013, 14, 15827-15837.

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