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Int. J. Mol. Sci. 2013, 14(8), 15578-15594; doi:10.3390/ijms140815578
Article

Phyto-SERM Constitutes from Flemingia macrophylla

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Received: 15 March 2013; in revised form: 6 July 2013 / Accepted: 15 July 2013 / Published: 26 July 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots’ methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).
Keywords: Flemingia macrophylla; menopausal; phytoestrogen; fleminigin; flemichin E; pER8:GUS Flemingia macrophylla; menopausal; phytoestrogen; fleminigin; flemichin E; pER8:GUS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lai, W.-C.; Tsui, Y.-T.; Singab, A.N.B.; El-Shazly, M.; Du, Y.-C.; Hwang, T.-L.; Wu, C.-C.; Yen, M.-H.; Lee, C.-K.; Hou, M.-F.; Wu, Y.-C.; Chang, F.-R. Phyto-SERM Constitutes from Flemingia macrophylla. Int. J. Mol. Sci. 2013, 14, 15578-15594.

AMA Style

Lai W-C, Tsui Y-T, Singab ANB, El-Shazly M, Du Y-C, Hwang T-L, Wu C-C, Yen M-H, Lee C-K, Hou M-F, Wu Y-C, Chang F-R. Phyto-SERM Constitutes from Flemingia macrophylla. International Journal of Molecular Sciences. 2013; 14(8):15578-15594.

Chicago/Turabian Style

Lai, Wan-Chun; Tsui, Ya-Ting; Singab, Abdel N.B.; El-Shazly, Mohamed; Du, Ying-Chi; Hwang, Tsong-Long; Wu, Chin-Chung; Yen, Ming-Hong; Lee, Ching-Kuo; Hou, Ming-Feng; Wu, Yang-Chang; Chang, Fang-Rong. 2013. "Phyto-SERM Constitutes from Flemingia macrophylla." Int. J. Mol. Sci. 14, no. 8: 15578-15594.



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