Next Article in Journal
Proteolytic Cleavage of Apolipoprotein E4 as the Keystone for the Heightened Risk Associated with Alzheimer’s Disease
Next Article in Special Issue
Transition Pathway and Its Free-Energy Profile: A Protocol for Protein Folding Simulations
Previous Article in Journal
Ectopic Expression of BraYAB1-702, a Member of YABBY Gene Family in Chinese Cabbage, Causes Leaf Curling, Inhibition of Development of Shoot Apical Meristem and Flowering Stage Delaying in Arabidopsis thaliana
Previous Article in Special Issue
Misfolding and Amyloid Aggregation of Apomyoglobin
Int. J. Mol. Sci. 2013, 14(7), 14892-14907; doi:10.3390/ijms140714892
Article

Structure Prediction of Partial-Length Protein Sequences

1
, 2
 and 2,*
Received: 26 April 2013; in revised form: 1 July 2013 / Accepted: 2 July 2013 / Published: 17 July 2013
(This article belongs to the Special Issue Protein Folding 2015)
View Full-Text   |   Download PDF [1137 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Protein structure information is essential to understand protein function. Computational methods to accurately predict protein structure from the sequence have primarily been evaluated on protein sequences representing full-length native proteins. Here, we demonstrate that top-performing structure prediction methods can accurately predict the partial structures of proteins encoded by sequences that contain approximately 50% or more of the full-length protein sequence. We hypothesize that structure prediction may be useful for predicting functions of proteins whose corresponding genes are mapped expressed sequence tags (ESTs) that encode partial-length amino acid sequences. Additionally, we identify a confidence score representing the quality of a predicted structure as a useful means of predicting the likelihood that an arbitrary polypeptide sequence represents a portion of a foldable protein sequence (“foldability”). This work has ramifications for the prediction of protein structure with limited or noisy sequence information, as well as genome annotation.
Keywords: protein structure prediction; EST; expressed sequence tag; protein folding; protein design protein structure prediction; EST; expressed sequence tag; protein folding; protein design
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Laurenzi, A.; Hung, L.-H.; Samudrala, R. Structure Prediction of Partial-Length Protein Sequences. Int. J. Mol. Sci. 2013, 14, 14892-14907.

AMA Style

Laurenzi A, Hung L-H, Samudrala R. Structure Prediction of Partial-Length Protein Sequences. International Journal of Molecular Sciences. 2013; 14(7):14892-14907.

Chicago/Turabian Style

Laurenzi, Adrian; Hung, Ling-Hong; Samudrala, Ram. 2013. "Structure Prediction of Partial-Length Protein Sequences." Int. J. Mol. Sci. 14, no. 7: 14892-14907.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert