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Int. J. Mol. Sci. 2013, 14(7), 13670-13686; doi:10.3390/ijms140713670
Review

Stem Cells behind the Barrier

1
, 2
 and 1,*
Received: 6 June 2013; Accepted: 25 June 2013 / Published: 28 June 2013
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells)
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Abstract: Epidermal stem cells sustain the adult skin for a lifetime through self-renewal and the production of committed progenitors. These stem cells generate progeny that will undergo terminal differentiation leading to the development of a protective epidermal barrier. Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balance leads to skin diseases. In this review, we summarize and discuss current advances in our understanding of the mechanisms regulating epidermal stem and progenitor cell differentiation, and explore new relationships for maintenance of skin barrier function.
Keywords: stem cell; epidermis; differentiation; proliferation; barrier; cancer; asymmetric cell division; epigenetic; microRNA; transcription factor stem cell; epidermis; differentiation; proliferation; barrier; cancer; asymmetric cell division; epigenetic; microRNA; transcription factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cangkrama, M.; Ting, S.B.; Darido, C. Stem Cells behind the Barrier. Int. J. Mol. Sci. 2013, 14, 13670-13686.

AMA Style

Cangkrama M, Ting SB, Darido C. Stem Cells behind the Barrier. International Journal of Molecular Sciences. 2013; 14(7):13670-13686.

Chicago/Turabian Style

Cangkrama, Michael; Ting, Stephen B.; Darido, Charbel. 2013. "Stem Cells behind the Barrier." Int. J. Mol. Sci. 14, no. 7: 13670-13686.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert