Int. J. Mol. Sci. 2013, 14(6), 12806-12826; doi:10.3390/ijms140612806

Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species

1,* email, 1email and 2email
Received: 22 April 2013; in revised form: 13 June 2013 / Accepted: 14 June 2013 / Published: 19 June 2013
(This article belongs to the Special Issue Molecular Research in Plant Secondary Metabolism)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Alternative medicinal agents, such as the herb Bupleurum, are increasingly used in modern medicine to supplement synthetic drugs. First, we present a review of the currently known effects of triterpene saponins-saikosaponins of Bupleurum species. The putative biosynthetic pathway of saikosaponins in Bupleurum species is summarized, followed by discussions on identification and characterization of genes involved in the biosynthesis of saikosaponins. The purpose is to provide a brief review of gene extraction, functional characterization of isolated genes and assessment of expression patterns of genes encoding enzymes in the process of saikosaponin production in Bupleurum species, mainly B. kaoi. We focus on the effects of MeJA on saikosaponin production, transcription patterns of genes involved in biosynthesis and on functional depiction.
Keywords: anti-hepatitis; anti-inflammation; Bupleurum species; ethylene response factor; medicinal herb; methyl jasmonate (MeJA); saikosaponin; triterpenoid
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MDPI and ACS Style

Lin, T.-Y.; Chiou, C.-Y.; Chiou, S.-J. Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species. Int. J. Mol. Sci. 2013, 14, 12806-12826.

AMA Style

Lin T-Y, Chiou C-Y, Chiou S-J. Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species. International Journal of Molecular Sciences. 2013; 14(6):12806-12826.

Chicago/Turabian Style

Lin, Tsai-Yun; Chiou, Chung-Yi; Chiou, Shu-Jiau. 2013. "Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species." Int. J. Mol. Sci. 14, no. 6: 12806-12826.

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