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Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species
Institute of Bioinformatics and Structural Biology & Department of Life Science, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Rd., Hsinchu 30013, Taiwan
Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, No. 321, Sec. 2, Kuang Fu Rd., Hsinchu 30011, Taiwan
* Author to whom correspondence should be addressed.
Received: 22 April 2013; in revised form: 13 June 2013 / Accepted: 14 June 2013 / Published: 19 June 2013
Abstract: Alternative medicinal agents, such as the herb Bupleurum, are increasingly used in modern medicine to supplement synthetic drugs. First, we present a review of the currently known effects of triterpene saponins-saikosaponins of Bupleurum species. The putative biosynthetic pathway of saikosaponins in Bupleurum species is summarized, followed by discussions on identification and characterization of genes involved in the biosynthesis of saikosaponins. The purpose is to provide a brief review of gene extraction, functional characterization of isolated genes and assessment of expression patterns of genes encoding enzymes in the process of saikosaponin production in Bupleurum species, mainly B. kaoi. We focus on the effects of MeJA on saikosaponin production, transcription patterns of genes involved in biosynthesis and on functional depiction.
Keywords: anti-hepatitis; anti-inflammation; Bupleurum species; ethylene response factor; medicinal herb; methyl jasmonate (MeJA); saikosaponin; triterpenoid
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Lin, T.-Y.; Chiou, C.-Y.; Chiou, S.-J. Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species. Int. J. Mol. Sci. 2013, 14, 12806-12826.
Lin T-Y, Chiou C-Y, Chiou S-J. Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species. International Journal of Molecular Sciences. 2013; 14(6):12806-12826.
Lin, Tsai-Yun; Chiou, Chung-Yi; Chiou, Shu-Jiau. 2013. "Putative Genes Involved in Saikosaponin Biosynthesis in Bupleurum Species." Int. J. Mol. Sci. 14, no. 6: 12806-12826.