Int. J. Mol. Sci. 2013, 14(6), 11626-11642; doi:10.3390/ijms140611626
Review

Epidermal Stem Cells in Orthopaedic Regenerative Medicine

1 Biomedical Engineering, the Johns Hopkins University School of Medicine, 720 Rutland Ave., Traylor #710B, Baltimore, MD 21205, USA 2 Orthopaedic Surgery, the Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross #229, Baltimore, MD 21205, USA 3 Anesthesiology and Critical Care Medicine, the Johns Hopkins University School of Medicine, 720 Rutland Ave., Traylor #710B, Baltimore, MD 21205, USA 4 Physical Medicine and Rehabilitation, the Johns Hopkins University School of Medicine, 720 Rutland Ave., Traylor #710B, Baltimore, MD 21205, USA
* Author to whom correspondence should be addressed.
Received: 10 April 2013; in revised form: 15 May 2013 / Accepted: 20 May 2013 / Published: 31 May 2013
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells)
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Abstract: In the last decade, great advances have been made in epidermal stem cell studies at the cellular and molecular level. These studies reported various subpopulations and differentiations existing in the epidermal stem cell. Although controversies and unknown issues remain, epidermal stem cells possess an immune-privileged property in transplantation together with easy accessibility, which is favorable for future clinical application. In this review, we will summarize the biological characteristics of epidermal stem cells, and their potential in orthopedic regenerative medicine. Epidermal stem cells play a critical role via cell replacement, and demonstrate significant translational potential in the treatment of orthopedic injuries and diseases, including treatment for wound healing, peripheral nerve and spinal cord injury, and even muscle and bone remodeling.
Keywords: epidermal stem cells; wound healing; peripheral nerve injury; spinal cord injury; molecular biology; orthopedic regenerative medicine

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MDPI and ACS Style

Li, J.; Zhen, G.; Tsai, S.-Y.; Jia, X. Epidermal Stem Cells in Orthopaedic Regenerative Medicine. Int. J. Mol. Sci. 2013, 14, 11626-11642.

AMA Style

Li J, Zhen G, Tsai S-Y, Jia X. Epidermal Stem Cells in Orthopaedic Regenerative Medicine. International Journal of Molecular Sciences. 2013; 14(6):11626-11642.

Chicago/Turabian Style

Li, Jin; Zhen, Gehua; Tsai, Shin-Yi; Jia, Xiaofeng. 2013. "Epidermal Stem Cells in Orthopaedic Regenerative Medicine." Int. J. Mol. Sci. 14, no. 6: 11626-11642.

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