Int. J. Mol. Sci. 2013, 14(6), 11496-11509; doi:10.3390/ijms140611496
Article

Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug

1 King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia 2 Central Metallurgical Research and Development Institute (CMRDI), P.O. Box 87, Helwan, Cairo 11421, Egypt 3 Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71111, Egypt 5 Department of Chemical Engineering, King Saud University, Riyadh 11421, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 16 February 2013; in revised form: 3 May 2013 / Accepted: 15 May 2013 / Published: 30 May 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract: In this work, Fe3O4@SiO2 nanoparticles were coated with mesoporous silica shell by SN+I pathway by using anionic surfactant (S) and co-structure directing agent (N+). The role of co-structure directing agent (CSDA) is to assist the electrostatic interaction between negatively charged silica layers and the negatively charged surfactant molecules. Prior to the mesoporous shell formation step, magnetic cores were coated with a dense silica layer to prevent iron oxide cores from leaching into the mother system under any acidic circumstances. However, it was found that both dense and mesoporous coating parameters affect the textural properties of the produced mesoporous silica shell (i.e., surface area, pore volume and shell thickness). The synthesized Fe3O4@SiO2@m-SiO2 (MCMSS) nanoparticles have been characterized by low-angle X-ray diffraction, transmission electron microscopy (TEM), and N2 adsorption-desorption analysis, and magnetic properties. The synthesized particles had dense and mesoporous silica shells of 8–37 nm and 26–50 nm, respectively. Furthermore, MCMSS possessed surface area of ca. 259–621 m2·g1, and pore volume of ca. 0.216–0.443 cc·g1. MCMSS showed docetaxcel cancer drug storage capacity of 25–33 w/w% and possessed control release from their mesochannels which suggest them as proper nanocarriers for docetaxcel molecules.
Keywords: mesoporous shell; Fe3O4; drug control release; core-shell; anionic surfactant

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MDPI and ACS Style

El-Toni, A.M.; Ibrahim, M.A.; Labis, J.P.; Khan, A.; Alhoshan, M. Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug. Int. J. Mol. Sci. 2013, 14, 11496-11509.

AMA Style

El-Toni AM, Ibrahim MA, Labis JP, Khan A, Alhoshan M. Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug. International Journal of Molecular Sciences. 2013; 14(6):11496-11509.

Chicago/Turabian Style

El-Toni, Ahmed M.; Ibrahim, Mohamed A.; Labis, Joselito P.; Khan, Aslam; Alhoshan, Mansour. 2013. "Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug." Int. J. Mol. Sci. 14, no. 6: 11496-11509.

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