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Int. J. Mol. Sci. 2013, 14(6), 11392-11401; doi:10.3390/ijms140611392
Article

The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis

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Received: 15 April 2013; Accepted: 17 May 2013 / Published: 28 May 2013
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Abstract: The -173 G/C polymorphism in the macrophage migration inhibitory factor (MIF) gene has been implicated in susceptibility to inflammatory bowel disease (IBD), but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -173 G/C polymorphism and IBD risk. We searched in Pubmed, and Embase for studies evaluating the association between the -173G/C gene polymorphism and IBD risk. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software. A total of seven publications involving 4729 subjects (2282 IBD cases and 2447 controls) were included in this meta-analysis. Combined analysis revealed a clear association between this polymorphism and IBD susceptibility (OR = 1.48, 95% CI: 1.10–2.00, p = 0.009 for CC vs. CG + GG). Subgroup analysis by ethnicity showed that the IBD risk associated with the -173G/C gene polymorphism was significantly elevated among Asians (OR = 1.79, 95% CI: 1.08–2.96, p = 0.02), but not among Caucasians. Subgroup analysis by disease suggested that the -173G/C gene polymorphism is a risk factor for ulcerative colitis (OR = 1.62, 95% CI: 1.10–2.37, p = 0.01), but that it was not associated with Crohn’s disease. This meta-analysis suggests that the -173 G/C polymorphism in the macrophage MIF gene contributes to IBD susceptibility, specifically in Asian populations. Further studies are needed to validate these findings.
Keywords: inflammatory bowel disease; migration inhibitory factor; polymorphism; susceptibility; meta-analysis inflammatory bowel disease; migration inhibitory factor; polymorphism; susceptibility; meta-analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shen, Y.; Guo, S.; Yang, T.; Jia, L.; Chen, L.; An, J.; Wang, T.; Wen, F. The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis. Int. J. Mol. Sci. 2013, 14, 11392-11401.

AMA Style

Shen Y, Guo S, Yang T, Jia L, Chen L, An J, Wang T, Wen F. The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis. International Journal of Molecular Sciences. 2013; 14(6):11392-11401.

Chicago/Turabian Style

Shen, Yongchun; Guo, Shujin; Yang, Ting; Jia, Liuqun; Chen, Lei; An, Jing; Wang, Tao; Wen, Fuqiang. 2013. "The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis." Int. J. Mol. Sci. 14, no. 6: 11392-11401.


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