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The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis
Division of Internal Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 15 April 2013; Accepted: 17 May 2013 / Published: 28 May 2013
Abstract: The -173 G/C polymorphism in the macrophage migration inhibitory factor (MIF) gene has been implicated in susceptibility to inflammatory bowel disease (IBD), but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -173 G/C polymorphism and IBD risk. We searched in Pubmed, and Embase for studies evaluating the association between the -173G/C gene polymorphism and IBD risk. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software. A total of seven publications involving 4729 subjects (2282 IBD cases and 2447 controls) were included in this meta-analysis. Combined analysis revealed a clear association between this polymorphism and IBD susceptibility (OR = 1.48, 95% CI: 1.10–2.00, p = 0.009 for CC vs. CG + GG). Subgroup analysis by ethnicity showed that the IBD risk associated with the -173G/C gene polymorphism was significantly elevated among Asians (OR = 1.79, 95% CI: 1.08–2.96, p = 0.02), but not among Caucasians. Subgroup analysis by disease suggested that the -173G/C gene polymorphism is a risk factor for ulcerative colitis (OR = 1.62, 95% CI: 1.10–2.37, p = 0.01), but that it was not associated with Crohn’s disease. This meta-analysis suggests that the -173 G/C polymorphism in the macrophage MIF gene contributes to IBD susceptibility, specifically in Asian populations. Further studies are needed to validate these findings.
Keywords: inflammatory bowel disease; migration inhibitory factor; polymorphism; susceptibility; meta-analysis
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Shen, Y.; Guo, S.; Yang, T.; Jia, L.; Chen, L.; An, J.; Wang, T.; Wen, F. The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis. Int. J. Mol. Sci. 2013, 14, 11392-11401.
Shen Y, Guo S, Yang T, Jia L, Chen L, An J, Wang T, Wen F. The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis. International Journal of Molecular Sciences. 2013; 14(6):11392-11401.
Shen, Yongchun; Guo, Shujin; Yang, Ting; Jia, Liuqun; Chen, Lei; An, Jing; Wang, Tao; Wen, Fuqiang. 2013. "The -173 G/C Polymorphism of the MIF Gene and Inflammatory Bowel Disease Risk: A Meta-Analysis." Int. J. Mol. Sci. 14, no. 6: 11392-11401.